Home > Name List By other > (4R,5S,6S)-3-[(3S, 5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1- hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2... India

CAS No 96036-03-2 , (4R,5S,6S)-3-[(3S,
5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-
hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic
acid Search by region : India

  • Name: (4R,5S,6S)-3-[(3S,
    5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-
    hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic
    acid
  • Synonyms: Meropenemum;96036-03-2; CHEBI:43968; Meropenem [INN]; SM-7338; DSSTox_CID_25526;(4R,5S,6S)-3-[(3S,
    5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-
    hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic
    acid; SM 7338; Meropenem (INN); ICI-194660;
  • CAS Registry Number:
  • Flash Point: 333.2 ºC
  • Boiling Point: 627.4 ºC at 760 mmHg
  • Density: 1.42 g/cm3
  • Refractive index: 1.639
  • Safety Statements: 26-37/39
  • Hazard Symbols: Xi: Irritant;
  • HS Code: 29419000
  • Flash Point: 333.2 ºC
  • Molecular Weight: 383.4625
  • InchiKey: DMJNNHOOLUXYBV-PQTSNVLCSA-N
  • InChI: InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-
    9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,
    10+,11-,12-/m1/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C17H25N3O5S
  • Molecular Structure:CAS No:96036-03-2 (4R,5S,6S)-3-[(3S,<br />5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-<br />hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic<br />acid

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96036-03-2 MEROPENEM

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96036-03-2 Meropenem

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References of (4R,5S,6S)-3-[(3S,
5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-
hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic
acid
Title: Meropenem
CAS Registry Number: 96036-03-2
CAS Name: (4R,5S,6S)-3-[[(3S,5S)-5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Synonyms: (1R,5S,6S)-2-[(3S,5S)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid
Molecular Formula: C17H25N3O5S
Molecular Weight: 383.46
Percent Composition: C 53.25%, H 6.57%, N 10.96%, O 20.86%, S 8.36%
Literature References: Carbapenem antibiotic. Prepn: M. Sunagawa et al., EP 126587; M. Sunagawa, US 4943569 (1984, 1990 both to Sumitomo). Structure-activity study: M. Sunagawa et al., J. Antibiot. 43, 519 (1990). Crystal structure: K. Yanagi et al., Acta Crystallogr. C48, 1737 (1992). HPLC determn in serum and bronchial secretions: M. Ehrlich et al., J. Chromatogr. B 751, 357 (2001). Pharmacokinetics: R. Wise et al., Antimicrob. Agents Chemother. 34, 1515 (1990). Series of articles on antimicrobial activity, metabolism: J. Antimicrob. Chemother. 24, Suppl. A, 1-320 (1989); and clinical performance: ibid. 36, Suppl. A, 1-223 (1995). Review of clinical experience in intensive care: M. Hurst, H. M. Lamb, Drugs 59, 653-680 (2000).
 
Derivative Type: Trihydrate
CAS Registry Number: 119478-56-7
Manufacturers' Codes: ICI-194660; SM-7338
Trademarks: Meronem (AstraZeneca); Meropen (Sumitomo); Merrem (AstraZeneca)
Properties: White to pale yellow crystalline powder. Sparingly sol in water; very slightly sol in hydrated ethanol. Practically insol in acetone, ether.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Carbapenems.