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CAS No 95847-70-4 , 1,1-dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,
2-benzothiazol-3-one Search by region : China

  • Name: 1,1-dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,
    2-benzothiazol-3-one
  • Synonyms: Ipsapirona; Ipsapironum [Latin]; BRN 5486134; NCGC00025315-01; Ipsapirona [Spanish]; Ipsapironum;1,1-dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,
    2-benzothiazol-3-one; DSSTox_CID_25688; Ipsapirone [INN:BAN];
  • CAS Registry Number:
  • Flash Point: 334.7°C
  • Boiling Point: 629.8°Cat760mmHg
  • Density: 1.345g/cm3
  • Refractive index: 1.622
  • Flash Point: 334.7°C
  • Molecular Weight: 401.48262
  • InchiKey: TZJUVVIWVWFLCD-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,
    27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,
    10-15H2
  • Molecular Formula: C19H23N5O3S
  • Molecular Structure:CAS No:95847-70-4 1,1-dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,<br />2-benzothiazol-3-one

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95847-70-4 IPSAPIRONE; 2-[4-[4-(PYRIMIDIN-2-YL)-(PIPERAZIN-1-YL)]BUTYL]-1,2-BENZISO THIAZOL-3(2H)-ONE-1,1-DIOXIDE

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  • Address: Rm.902 Longyin Plaza,
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    (N)Nanjing 210009,China null,nullChina
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1/1
References of 1,1-dioxo-2-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,
2-benzothiazol-3-one
Title: Ipsapirone
CAS Registry Number: 95847-70-4
CAS Name: 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazolin-3(2H)-one 1,1-dioxide
Synonyms: isapirone
Molecular Formula: C19H23N5O3S
Molecular Weight: 401.48
Percent Composition: C 56.84%, H 5.77%, N 17.44%, O 11.96%, S 7.99%
Literature References: Nonbenzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist. Prepn: W. Dompert et al., DE 3321969; P.-R. Seidel et al., US 4818756 (1984, 1989 both to Troponwerke). Pharmacology and serotonin (5-HT1) receptor binding study: J. Traber et al., Brain Res. Bull. 12, 741 (1984). 5-HT1 specific binding activity: W. U. Dompert et al., Arch. Pharmacol. 328, 467 (1985); T. Glaser, J. Traber, ibid. 329, 211 (1985). Behavioral effects in mice: R. J. DeSouza et al., Br. J. Pharmacol. 89, 377 (1986). Neurophysiological effects in comparison with buspirone. M. J. Rowan, R. Anwyl, Eur. J. Pharmacol. 132, 93 (1987). HPLC determn in biological samples: G. Bianchi, S. Caccia, J. Chromatogr. 431, 477 (1988).
Properties: Crystals from isopropanol, mp 137-138°.
Melting point: mp 137-138°
 
Derivative Type: Hydrochloride
CAS Registry Number: 92589-98-5
Manufacturers' Codes: Bay q 7821; TVX Q 7821
Molecular Formula: C19H23N5O3S.HCl
Molecular Weight: 437.94
Percent Composition: C 52.11%, H 5.52%, N 15.99%, O 10.96%, S 7.32%, Cl 8.10%
Properties: Crystals from isopropanol, mp 221-222°.
Melting point: mp 221-222°
 
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Arylpiperazines; Serotonin Receptor Agonist.