Home > Name List By other > (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3, 4-dihydrochromene-6-carbonitrile

CAS No 94535-50-9 , (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,
4-dihydrochromene-6-carbonitrile

  • Name: (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,
    4-dihydrochromene-6-carbonitrile
  • Synonyms: BRN 3622889; Cromakalim;Levcromakalim; Lemakalim; BRL-38227; BRL 38227;(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,
    4-dihydrochromene-6-carbonitrile; Levcromakelim; (-)-Cromakalim; DSSTox_CID_25677;
  • CAS Registry Number:
  • Flash Point: 245.5°C
  • Boiling Point: 482.3°Cat760mmHg
  • Density: 1.31g/cm3
  • Safety Statements: 22-24/25
  • Flash Point: 245.5°C
  • Molecular Weight: 286.32572
  • InchiKey: TVZCRIROJQEVOT-CABCVRRESA-N
  • InChI: InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-
    12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
  • Molecular Formula: C16H18N2O3
  • Molecular Structure:CAS No:94535-50-9 (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,<br />4-dihydrochromene-6-carbonitrile

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  • (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrileLevcromakalim, >99%
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94535-50-9 Levcromakalim

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94535-50-9 LEVCROMAKALIM; (3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PY RROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE

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References of (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,
4-dihydrochromene-6-carbonitrile
Title: Levcromakalim
CAS Registry Number: 94535-50-9
CAS Name: (3S-trans)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Synonyms: (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile; (-)-6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-(2-oxo-1-pyrrolidinyl)-2H-benzo[b]pyran-3-ol; lemakalim; (-)-cromakalim
Manufacturers' Codes: BRL-38227
Molecular Formula: C16H18N2O3
Molecular Weight: 286.33
Percent Composition: C 67.12%, H 6.34%, N 9.78%, O 16.76%
Literature References: Potassium channel opener. Prepn of racemate: J. M. Evans et al., EP 76075; eidem, US 4446113 (1983, 1984 both to Beecham); of isomers: E. Faruk, EP 120428 (1984 to Beecham); V. A. Ashwood et al., J. Med. Chem. 29, 2194 (1986). Mechanism of action and hemodynamic effects: R. P. Hof et al., Circ. Res. 62, 679 (1988). Pharmacology: J. C. Clapham et al., Arzneim.-Forsch. 41, 385 (1991). Clinical evaluation in hypertension: S. Suzuki et al., ibid. 45, 859 (1995).
Properties: Crystals from ethyl acetate, mp 242-244°. [a]D26 -52.2° (c = 1 in chloroform).
Melting point: mp 242-244°
Optical Rotation: [a]D26 -52.2° (c = 1 in chloroform)
 
Derivative Type: (+)-Form
Properties: Crystals from ethyl acetate, mp 243-245°. [a]D26 +53.5° (c = 1 in chloroform).
Melting point: mp 243-245°
Optical Rotation: [a]D26 +53.5° (c = 1 in chloroform)
 
Derivative Type: (±)-Form
CAS Registry Number: 94470-67-4
Synonyms: Cromakalim
Manufacturers' Codes: BRL-34915
Properties: Crystals from ethyl acetate, mp 230-231°.
Melting point: mp 230-231°
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Potassium Channel Activator/Opener.