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CAS No 94-78-0 , 3-phenyldiazenylpyridine-2,6-diamine

  • Name: 3-phenyldiazenylpyridine-2,6-diamine
  • Synonyms: Pyridiate;3-phenyldiazenylpyridine-2,6-diamine; Urogesic; Viridium; Gastracid; Urodine; Phenazodine; Pyridacil; Baridium; Sedural;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 235 - 240 C
  • Flash Point: 442.3°Cat760mmHg
  • Boiling Point: 442.3°Cat760mmHg
  • Density: 1.32g/cm3
  • Hazard Symbols: UN NO.
  • Flash Point: 442.3°Cat760mmHg
  • EINECS: 202-363-2, 205-243-8
  • Molecular Weight: 213.23854
  • InchiKey: QPFYXYFORQJZEC-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H11N5/c12-10-7-6-9(11(13)14-10)16-15-8-4-2-1-3-5-8/h1-7H,
    (H4,12,13,14)
  • Molecular Formula: C11H11N5
  • Molecular Structure:CAS No:94-78-0 3-phenyldiazenylpyridine-2,6-diamine

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94-78-0 Phenazopyridine

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References of 3-phenyldiazenylpyridine-2,6-diamine
Title: Phenazopyridine
CAS Registry Number: 94-78-0
CAS Name: 3-(Phenylazo)-2,6-pyridinediamine
Synonyms: 2,6-diamino-3-phenylazopyridine; b-phenylazo-a,a￠-diaminopyridine
Molecular Formula: C11H11N5
Molecular Weight: 213.24
Percent Composition: C 61.96%, H 5.20%, N 32.84%
Literature References: Azo dye used in treatment of urinary tract infections. Prepn: A. E. Chichibabin, O. A. Zeide, J. Russ. Phys. Chem. Soc. 46, 1216 (1914); Chem. Zentralbl. 1915, I, 1064; I. Ostromislensky, US 1680109 (1928 to Pyridium); and bacteriostatic properties: R. N. Shreve et al., J. Am. Chem. Soc. 65, 2241 (1943). Physical characteristics: G. W. Collins, J. Am. Pharm. Assoc. 20, 455 (1931). Toxicity data: B. A. Becker, J. G. Swift, Toxicol. Appl. Pharmacol. 1, 42 (1959). Comprehensive description: K. W. Blessel et al., Anal. Profiles Drug Subs. 3, 465-482 (1974). LC-MS determn in plasma and pharmacokinetics: E. Shang et al., Anal. Bioanal. Chem. 382, 216 (2005). Review of clinical experience in urinary tract infections: S. A. Zelenitsky, G. G. Zhanel, Ann. Pharmacother. 30, 866-868 (1996).
Properties: mp 136-137°.
Melting point: mp 136-137°
 
Derivative Type: Hydrochloride
CAS Registry Number: 136-40-3
Trademarks: Prodium (Breckenridge); Pyridium (Warner-Chilcott); Pyridacil (Cilag); Sedural (Rekah)
Molecular Formula: C11H11N5.HCl
Molecular Weight: 249.70
Percent Composition: C 52.91%, H 4.84%, N 28.05%, Cl 14.20%
Properties: Brick-red microcrystals, slight violet luster. Slightly bitter taste. Slightly sol in cold water, about 1 part in 300; sol in boiling water, about 1 part in 20. One part is sol in about 100 parts glycerol. Sol in ethylene and propylene glycols. Slightly sol in alc, lanolin; sol in acetic acid. Insol in acetone, benzene, chloroform, ether, toluene. Aq solns are yellow to brick-red and slightly acid. Forms supersatd solns easily. Will precipitate out of a 2% soln at 25° after about 2 days, out of a 1% soln only after months. Aq solns may be stabilized by the addn of 10% glucose. LD50 orally in rats: 403 mg/kg (Becker, Swift).
Toxicity data: LD50 orally in rats: 403 mg/kg (Becker, Swift)
 
CAUTION: Phenazopyridine hydrochloride is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-213.
Therap-Cat: Analgesic (urinary tract).
Therap-Cat-Vet: Analgesic (urinary tract).
Keywords: Analgesic (Non-Narcotic).