CAS No 94-20-2 , 1-(4-chlorophenyl)sulfonyl-3-propylurea Search by region : Germany

Name: 1-(4-chlorophenyl)sulfonyl-3-propylurea
Synonyms: Chlorpropamid; Diabaril; Meldian; Diabeneza; Diabenese;Chloropropamide; Diabetoral; Dynalase; Diabinese;1-(4-chlorophenyl)sulfonyl-3-propylurea;
CAS Registry Number:94-20-2
Melting Point: 128 °C
Density: 1.334 g/cm³
Safety Statements: Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: hemolysis with or without anemia, ulceration or bleeding from large intestine, cholestatic jaundice. Human teratogenic effects by ingestion: fetal death. Human reproductive effects by ingestion and possibly other routes: stillbirth, reduced viability and abnormal characteristics of newborn at birth. An experimental teratogen. Experimental reproductive effects. Mutation data reported. An antidiabetic agent. When heated to decomposition it emits very toxic fumes of Cl⁻, NO_x, and SO_x.
Hazard Symbols: Xn: Harmful;
EINECS: 202-314-5
Molecular Weight: 276.73982
InchiKey: RKWGIWYCVPQPMF-UHFFFAOYSA-N
InChI: InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,
16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)
Risk Statements: 20/21/22-40
Molecular Formula: C₁₀H₁₃ClN₂O₃S
Molecular Structure:

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References of 1-(4-chlorophenyl)sulfonyl-3-propylurea

Title: Chlorpropamide
CAS Registry Number: 94-20-2
CAS Name: 4-Chloro-N-[(propylamino)carbonyl]benzenesulfonamide
Synonyms: 1-(p-chlorophenylsulfonyl)-3-propylurea; 1-(p-chlorobenzenesulfonyl)-3-propylurea; N-propyl-N￠-(p-chlorobenzenesulfonyl)urea
Manufacturers' Codes: P-607
Trademarks: Adiaben; Asucrol; Catanil (DeAngeli); Chloronase (Hoechst); Diabechlor; Diabenal; Diabetoral (Boehringer, Mann.); Diabinese (Pfizer); Melitase (Berk); Millinese (Lampugnani); Oradian (Chinoin); Stabinol (Horner)
Molecular Formula: C10H13ClN2O3S
Molecular Weight: 276.74
Percent Composition: C 43.40%, H 4.73%, Cl 12.81%, N 10.12%, O 17.34%, S 11.59%
Literature References: Prepn: Marshall, Sigal, J. Org. Chem. 23, 927 (1958); GB 853555; W. M. McLamore, US 3349124 (1960, 1967 both to Pfizer); Bauer et al., J. Org. Chem. 31, 3440 (1960). Pharmacology and metabolism: Khurana et al., Indian J. Med. Res. 55, 1084 (1967); Brotherton et al., Clin. Pharmacol. Ther. 10, 505 (1969); Madsen et al., Eur. J. Pharmacol. 13, 374 (1971). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: Crystals from dil ethanol, mp 127-129°. uv max (0.01N HCl): 232.5 nm (e 16500). Soly in water at pH 6: 2.2 mg/ml. Practically insol at pH 7.3. Sol in alc; moderately sol in chloroform; sparingly sol in ether, benzene. LD50 i.p. in rats: 580 mg/kg (Goldenthal).
Melting point: mp 127-129°
Absorption maximum: uv max (0.01N HCl): 232.5 nm (e 16500)
Toxicity data: LD50 i.p. in rats: 580 mg/kg (Goldenthal)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives.