Title: Chlorpropamide
CAS Registry Number: 94-20-2
CAS Name: 4-Chloro-
N-[(propylamino)carbonyl]benzenesulfonamide
Synonyms: 1-(
p-chlorophenylsulfonyl)-3-propylurea; 1-(
p-chlorobenzenesulfonyl)-3-propylurea;
N-propyl-
N¢-(
p-chlorobenzenesulfonyl)urea
Manufacturers' Codes: P-607
Trademarks: Adiaben; Asucrol; Catanil (DeAngeli); Chloronase (Hoechst); Diabechlor; Diabenal; Diabetoral (Boehringer, Mann.); Diabinese (Pfizer); Melitase (Berk); Millinese (Lampugnani); Oradian (Chinoin); Stabinol (Horner)
Molecular Formula: C10H13ClN2O3S
Molecular Weight: 276.74
Percent Composition: C 43.40%, H 4.73%, Cl 12.81%, N 10.12%, O 17.34%, S 11.59%
Literature References: Prepn: Marshall, Sigal,
J. Org. Chem. 23, 927 (1958);
GB 853555; W. M. McLamore,
US 3349124 (1960, 1967 both to Pfizer); Bauer
et al., J. Org. Chem. 31, 3440 (1960). Pharmacology and metabolism: Khurana
et al., Indian J. Med. Res. 55, 1084 (1967); Brotherton
et al., Clin. Pharmacol. Ther. 10, 505 (1969); Madsen
et al., Eur. J. Pharmacol. 13, 374 (1971). Toxicity study: E. I. Goldenthal,
Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: Crystals from dil ethanol, mp 127-129°. uv max (0.01
N HCl): 232.5 nm (e 16500). Soly in water at pH 6: 2.2 mg/ml. Practically insol at pH 7.3. Sol in alc; moderately sol in chloroform; sparingly sol in ether, benzene. LD50 i.p. in rats: 580 mg/kg (Goldenthal).
Melting point: mp 127-129°
Absorption maximum: uv max (0.01
N HCl): 232.5 nm (e 16500)
Toxicity data: LD50 i.p. in rats: 580 mg/kg (Goldenthal)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives.