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CAS No 93957-54-1 , Fluvastatin Search by region : China

  • Name: Fluvastatin
  • CAS Registry Number:
  • Melting Point: 194-197ºC
  • Density: 1.23 g/cm3
  • Water Solubility: 0.46 mg/L in water
  • Molecular Weight: 411.47
  • InChI: InChI=1/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m0/s1
  • Molecular Formula: C24H26FNO4
  • Molecular Structure:CAS No:93957-54-1 Fluvastatin

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References of Fluvastatin
Title: Fluvastatin
CAS Registry Number: 93957-54-1
CAS Name: (3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
Synonyms: (±)-(3R*,5S*,6E)-7-[3-(p-fluorophenyl)-1-isopropylindol-2-yl]-3,5-dihydroxy-6-heptenoate
Molecular Formula: C24H26FNO4
Molecular Weight: 411.47
Percent Composition: C 70.06%, H 6.37%, F 4.62%, N 3.40%, O 15.55%
Literature References: Synthetic HMG-CoA reductase inhibitor. Prepn: F. G. Kathawala, WO 8402131; idem, US 4739073 (1984, 1988 both to Sandoz). Clinical pharmacology: J. Yuan et al., Atherosclerosis 87, 147 (1991). Clinical pharmacokinetics: F. L. S. Tse et al., J. Clin. Pharmacol. 32, 630 (1992). Metabolism in humans: J. G. Dain et al., Drug Metab. Dispos. 21, 567 (1993). HPLC determn in plasma: G. Kalafsky et al., J. Chromatogr. 614, 307 (1993). Clinical study in familial hypercholesterolaemia: E. Leitersdorf et al., Eur. J. Clin. Pharmacol. 45, 513 (1993); in prevention of cardiac events following percutaneous coronary intervention: P. W. J. Serruys et al., J. Am. Med. Assoc. 287, 3215 (2002). Review of pharmacology and therapeutic use: R. I. Levy et al., Circulation 87, Suppl. III, III-45-III-53 (1993).
 
Derivative Type: Sodium salt
CAS Registry Number: 93957-55-2
Synonyms: Fluindostatin
Manufacturers' Codes: XU 62-320
Trademarks: Lescol (Novartis); Lipaxan (Italfarmaco); Primexin (Wander)
Molecular Formula: C24H25FNNaO4
Molecular Weight: 433.45
Percent Composition: C 66.50%, H 5.81%, F 4.38%, N 3.23%, Na 5.30%, O 14.76%
Properties: mp 194-197°.
Melting point: mp 194-197°
 
Therap-Cat: Antilipemic.
Keywords: Antilipemic; HMG CoA Reductase Inhibitors; HMG CoA Reductase Inhibitor.