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CAS No 91374-21-9 , 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one

  • Name: 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
  • Synonyms: ReQuip CR; 91374-21-9; Ropinirol [INN-Spanish]; ReQuip XL; Ropinirolum; ropinirol; Ropinirolum [INN-Latin];ReQuip;4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one;
  • CAS Registry Number:
  • Melting Point: 243-250 ºC
  • Density: 1.04 g/cm3
  • Refractive index: 1.538
  • Molecular Weight: 260.37456
  • InchiKey: UHSKFQJFRQCDBE-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-
    15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19)
  • Molecular Formula: C16H24N2O
  • Molecular Structure:CAS No:91374-21-9 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one

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References of 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
Title: Ropinirole
CAS Registry Number: 91374-21-9
CAS Name: 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one
Synonyms: 4-[2-(di-n-propylamino)ethyl]-2(3H)-indolone
Manufacturers' Codes: SKF-101468
Molecular Formula: C16H24N2O
Molecular Weight: 260.37
Percent Composition: C 73.81%, H 9.29%, N 10.76%, O 6.14%
Literature References: Selective dopamine D2-receptor agonist. Prepn: G. Gallagher, Jr., US 4452808 (1984 to Smithkline Beckman); idem et al., J. Med. Chem. 28, 1533 (1985). HPLC determn in plasma: J. E. Swagzdis, B. A. Mico, J. Pharm. Sci. 75, 90 (1986). Pharmacology and receptor binding study: R. J. Eden et al., Pharmacol. Biochem. Behav. 38, 147 (1991). Clinical pharmacology, pharmacokinetics: C. de Mey et al., Br. J. Clin. Pharmacol. 32, 483 (1991). Clinical trials in Parkinson's disease: O. Rascol et al., Mov. Disord. 13, 39 (1998); A. D. Korczyn et al., ibid. 46; in restless legs syndrome: A. S. Walters et al., ibid. 19, 1414 (2004).
 
Derivative Type: Hydrochloride
CAS Registry Number: 91374-20-8
Manufacturers' Codes: SKF-101468A
Trademarks: Requip (GSK)
Molecular Formula: C16H24N2O.HCl
Molecular Weight: 296.84
Percent Composition: C 64.74%, H 8.49%, N 9.44%, O 5.39%, Cl 11.94%
Properties: Crystals from acetonitrile, mp 241-243°.
Melting point: mp 241-243°
 
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian; Dopamine Receptor Agonist.