Title: Dextran Sulfate Sodium
CAS Registry Number: 9011-18-1
Synonyms: Dextran sulfuric acid ester sodium salt
Trademarks: Asuro (Nippon Kayaku); Colyonal (Mochida); Dexulate; Dextrarine; MDS
Literature References: Heparin-like polysaccharide containing approx. 17% S with up to three sulfate groups per glucose molecule. Mol wt ranges from 4,000-500,000 Da; variations in mol wt are associated with differences in biological activity. Prepn, properties and anticoagulant activity: A. Gr?nwall
et al., Upsala Laekarefoeren. Foerh. 50, 397 (1945); C. R. Ricketts,
Biochem. J. 51, 129 (1952). Evaluation of toxicity as a function of mol wt: K. W. Walton,
Br. J. Pharmacol. 9, 1 (1954); of carcinogenicity: I. Hirono
et al., Cancer Lett. 18, 29 (1983). Use in serum HDL cholesterol determn: P. R. Finley
et al., Clin. Chem. 24, 931 (1978); G. R. Warnick
et al., ibid. 28, 1379 (1982). Antiscrapie effect: B. Ehlers, H. Diringer,
J. Gen. Virol. 65, 1325 (1984); R. H. Kimberlin, C. A. Walker,
Antimicrob. Agents Chemother. 30, 409 (1986). Anti-HIV-1 activity
in vitro: H. Mitsuya
et al., Science 240, 646 (1988); M. Baba
et al., Proc. Natl. Acad. Sci. USA 85, 6132 (1988).
Properties: White powder from alcohol + ether. Freely sol in water. Activity about 17 international heparin units/mg. Aq solns must be buffered (
e.g., with sodium bicarbonate) to prevent dec during autoclaving.
Use: Clinical reagent (HDL cholesterol determn).
Therap-Cat: Anticoagulant.
Keywords: Anticoagulant.
