Title: Phosvitin
CAS Registry Number: 9008-96-2
Literature References: A phosphoprotein of mol wt about 40,000. Isoln from egg yolk: Mecham, Olcott,
J. Am. Chem. Soc. 71, 3670 (1949);
Biochem. Prep. 2, 15 (1952); Joubert, Cook,
Can. J. Biochem. Physiol. 36, 399 (1958); from roe: Mano, Yoshida,
J. Biochem. (Tokyo) 66, 105 (1969). Represents about 7% of the total yolk protein; high in phosphorus content and a ratio of serine to all other amino acid residues of 6:4.
In vitro synthesis in hens liver: Heald, McLachlan,
Biochem. J. 94, 32 (1965); Rudack, Wallace,
Biochim. Biophys. Acta 155, 299 (1968). Estradiol-induced synthesis in roosters: Veuving, Gruber,
ibid. 232, 524, 529 (1971); Jailkhani, Talwar,
Nature New Biol. 236, 239 (1972). Amino acid sequence: Belitz,
Angew. Chem. 76, 574 (1964); Shainkin, Perlmann,
J. Biol. Chem. 246, 2278 (1971). Conformation: Grizzuti, Perlmann,
ibid. 245, 2573 (1970). Anticlotting activity studies: Sato
et al., Am. J. Physiol. 203, 1170 (1962).
Review: Taborsky,
Adv. Protein Chem. 28, 50-78 (1974).
Therap-Cat: Anticoagulant.
Keywords: Anticoagulant.
