Title: Diamine Oxidase
CAS Registry Number: 9001-53-0
Synonyms: Histaminase; benzylamine oxidase; histamine deaminase; histamine oxidase; DAO; EC 1.4.3.6
Literature References: Copper containing enzyme present in various tissues, esp in the intestinal mucosa; catalyzes the oxidative deamination of histamine and other biogenic amines to form the corresponding aldehydes, ammonia and hydrogen peroxide. Rate-limiting enzyme in the terminal catabolism of polyamines that are essential for cell proliferation. Discovery of a histamine-inactivating enzyme in lung tissue: C. H. Best,
J. Physiol. 67, 256 (1929). Identification of activity on other diamines: E. A. Zeller,
Helv. Chim. Acta 21, 880 (1938). Extraction from hog kidneys: B. Swedin,
Acta Med. Scand. 114, 21 (1943). Improved purification: D. Wilflingseder, H. G. Schwelberger,
J. Chromatogr. B 737, 161 (2000). HPLC determn in plasma: P. A. Biondi
et al., J. Chromatogr. 507, 333 (1990).
Reviews: F. Buffoni,
Pharmacol. Rev. 18, 1163-1199 (1966); M. C. J. Wolvekamp, R. W. F. de Bruin,
Dig. Dis. 12, 2-14 (1994). Review of role in polyamine metabolism: A. Sessa, A. Perin,
Agents Actions 43, 69-77 (1994); of role in cell growth and differentiation: P. Pietrangeli, B. Mondovi,
Neurotoxicology 25, 317-324 (2004).