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CAS No 89786-04-9 , (2S,3S,5R)-3-methyl-4,4,
7-trioxo-3-(triazol-1-ylmethyl)-4λ Search by region : Germany

  • Name: (2S,3S,5R)-3-methyl-4,4,
    7-trioxo-3-(triazol-1-ylmethyl)-4λ
  • Synonyms: YTR-830H; YTR830H; CHEBI:100207; DB01606; CHEMBL404;89786-04-9; BIDD:GT0212; AC1L3X07; AC-7620;(2S,3S,5R)-3-methyl-4,4,
    7-trioxo-3-(triazol-1-ylmethyl)-4λ6-thia-1-azabicyclo[3.2.0]heptane-
    2-carboxylic acid;
  • CAS Registry Number:
  • Flash Point: 381.4 ºC
  • Boiling Point: 707.1 ºCat 760 mmHg
  • Density: 1.92 g/cm3
  • Refractive index: 1.817
  • Safety Statements: S26;S36
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 381.4 ºC
  • Molecular Weight: 300.29108
  • InchiKey: LPQZKKCYTLCDGQ-WEDXCCLWSA-N
  • InChI: InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20
    (10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1
  • Risk Statements: R36/37/38
  • Molecular Formula: C10H12N4O5S
  • Molecular Structure:CAS No:89786-04-9 (2S,3S,5R)-3-methyl-4,4,<br />7-trioxo-3-(triazol-1-ylmethyl)-4λ

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89786-04-9 TAZOBACTAM

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References of (2S,3S,5R)-3-methyl-4,4,
7-trioxo-3-(triazol-1-ylmethyl)-4λ
Title: Tazobactam
CAS Registry Number: 89786-04-9
CAS Name: (2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
Synonyms: 2b-[(1,2,3-triazol-1-yl)methyl]-2a-methylpenam-3a-carboxylic acid 1,1-dioxide
Manufacturers' Codes: YTR-830H; CL-298741
Molecular Formula: C10H12N4O5S
Molecular Weight: 300.29
Percent Composition: C 40.00%, H 4.03%, N 18.66%, O 26.64%, S 10.68%
Literature References: b-Lactamase inhibitor. Prepn: R. G. Micetich et al., EP 97446; eidem, US 4562073 (1984, 1985 both to Taiho); R. G. Micetich et al., J. Med. Chem. 30, 1469 (1987). Degradation in solution: T. Marunaka et al., Chem. Pharm. Bull. 36, 4478 (1988); in solid state: E. Matsushima et al., ibid. 4593. b-Lactamase inhibiting activity in comparison with clavulanic acid and sulbactam, q.q.v., vs aerobes: M. R. Jacobs et al., Antimicrob. Agents Chemother. 29, 980 (1986); vs anaerobes: P. C. Appelbaum et al., ibid. 30, 789. HPLC determn in biological materials: T. Marunaka et al., J. Chromatogr. 431, 87 (1988). Clinical trial in combination with piperacillin, q.v.: I. M. Gould et al., Drugs Exp. Clin. Res. 17, 187 (1991).
 
Derivative Type: Sodium salt
CAS Registry Number: 89785-84-2
Manufacturers' Codes: YTR-830; CL-307579
Molecular Formula: C10H11N4NaO5S
Molecular Weight: 322.27
Percent Composition: C 37.27%, H 3.44%, N 17.39%, Na 7.13%, O 24.82%, S 9.95%
Properties: Amorphous solid, mp >170° (dec).
Melting point: mp >170° (dec)
 
Derivative Type: Combination of sodium salt with piperacillin sodium
Trademarks: Tazocilline (Wyeth); Tazocin (Wyeth); Zosyn (Wyeth)
 
Therap-Cat: In combination with b-lactam antibiotics as antibacterial.
Keywords: Antibacterial Adjuncts; ?Lactamase Inhibitors.