CAS No 89-38-3 , L-Glutamic acid,N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl-L-g-glutamyl-

Name: L-Glutamic acid,N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl-L-g-glutamyl-
Synonyms: L-Glutamicacid, N-[N-[N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl]-L-g-glutamyl]-;L-Glutamic acid,N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl-L-g-glutamyl-; PTGA; Fermentation L.casei factor; Pteroyl-L-glutamyl-g-L-glutamyl-g-L-glutamic acid;Pteroyltriglutamic acid; Pteropterin; Pteroyl-g-triglutamic acid; Pteroyltri-g-L-glutamic acid;Glutamicacid, N-[N-(N-pteroyl-L-g-glutamyl)-L-g-glutamyl]-, L- (6CI,7CI,8CI); L-Glutamic acid,N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl-L-g-glutamyl- (9CI); Folic acid diglutamate;
CAS Registry Number:89-38-3
Refractive index: 1.691
Molecular Weight: 0
InChI: InChI=1/C29H33N9O12/c30-29-37-23-22(25(44)38-29)33-15(12-32-23)11-31-14-3-1-13(2-4-14)24(43)36-18(28(49)50)6-9-20(40)34-16(26(45)46)5-8-19(39)35-17(27(47)48)7-10-21(41)42/h1-4,12,16-18,31H,5-11H2,(H,34,40)(H,35,39)(H,36,43)(H,41,42)(H,45,46)(H,47,48)(H,49,50)(H3,30,32,37,38,44)/t16-,17-,18-/m0/s1
Molecular Formula: C29H33N9O12
Molecular Structure:

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References of L-Glutamic acid,N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl-L-g-glutamyl-

Title: Pteropterin
CAS Registry Number: 89-38-3
CAS Name: N-[N-[N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl]-L-glutamyl]-L-glutamic acid
Synonyms: N-[N-(N-pteroyl-g-glutamyl)-g-glutamyl]glutamic acid; fermentation L. casei Factor; pterolyl-g-glutamyl-g-glutamylglutamic acid; pteroyldi-g-glutamylglutamic acid; pteroyltriglutamic acid; PTGA
Trademarks: Teropterin
Molecular Formula: C29H33N9O12
Molecular Weight: 699.63
Percent Composition: C 49.78%, H 4.75%, N 18.02%, O 27.44%
Literature References: Isoln from aerobic culture of Corynebacterium: Hutchings et al., J. Am. Chem. Soc. 70, 1 (1948). Identification, structure and synthesis: Boothe et al., ibid. 1099; ibid. 71, 2304 (1949). Prepn: Cosulich, US 2563707 (1951 to Am. Cyanamid).
Properties: Forms a crystalline barium salt.

Derivative Type: Monohydrate
Properties: Crystals from water adjusted to pH 2.8 with HCl and contg some NaCl. Has the general properties of a polypeptide. Absorption spectrum, Hutchings, loc. cit. Soly in water at 5°: 0.10 mg/ml; at 80°: 3.00 mg/ml. Sol in NaOH solns.

Derivative Type: Methyl ester
Properties: Crystals from methanol contg NaCl. Soly in water at 5°: 0.12 mg/ml; at 80°: 1.00 mg/ml; in methanol at -5°: 0.30 mg/ml; at 60°: 5.00 mg/ml.

Therap-Cat: Formerly as antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Folic Acid Analogs/Antagonists.