Home > Name List By other > (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4, 7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carbo... India

CAS No 88768-40-5 , (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,
7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid Search by region : India

  • Name: (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,
    7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid
  • Synonyms: Dynorm; 88768-40-5; Inibace; NCGC00182039-01; Cilazil;(4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,
    7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid; Cilazaprilum;Inhibace; Cilazaprilum [Latin]; Vascace;
  • CAS Registry Number:
  • Density: 1.26g/cm3
  • Safety Statements: 22-24/25
  • EINECS: 279-694-4
  • Molecular Weight: 417.49864
  • InchiKey: HHHKFGXWKKUNCY-FHWLQOOXSA-N
  • InChI: InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-
    14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,
    10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1
  • Molecular Formula: C22H31N3O5
  • Molecular Structure:CAS No:88768-40-5 (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,<br />7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid

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88768-40-5 CILAZAPRIL

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88768-40-5 Cilazapril

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References of (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,
7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid
Title: Cilazapril
CAS Registry Number: 88768-40-5
CAS Name: (1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
Synonyms: (1S,9S)-9-[[(S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid 9-ethyl ester
Manufacturers' Codes: Ro-31-2848
Trademarks: Dynorm (Roche)
Molecular Formula: C22H31N3O5
Molecular Weight: 417.50
Percent Composition: C 63.29%, H 7.48%, N 10.06%, O 19.16%
Literature References: Angiotensin-converting enzyme (ACE) inhibitor; hydrolyzed in vivo to the active diacid metabolite. Prepn: M. R. Attwood et al., DE 3317290; eidem, US 4512924 (1983, 1985 both to Hoffmann-La Roche); eidem, J. Chem. Soc. Perkin Trans. 1 1986, 1011. HPLC determn in urine and pharmaceutical formulations: J. A. Prieto et al., J. Chromatogr. B 714, 285 (1998). Pharmacology: I. L. Natoff et al., J. Cardiovasc. Pharmacol. 7, 569 (1985). Review of clinical pharmacology: C. H. Kleinbloesem et al., Am. J. Med. 87, Suppl. 6B, 45S-49S (1989). Review of clinical experience in hypertension: T. Szucs, Drugs 41, Suppl. 1, 18-24 (1991); in chronic heart failure: L. D?ssegger et al., J. Cardiovasc. Pharmacol. 24, Suppl. 3, S38-S41 (1994); in combination with hydrochlorothiazide: R. C. Pordy, Cardiology 86, 41-48 (1995).
 
Derivative Type: Monohydrate
CAS Registry Number: 92077-78-6
Trademarks: Inhibace (Roche); Initiss (Pharmacia); Justor (Chiesi); Vascace (Roche)
Molecular Formula: C22H31N3O5.H2O
Molecular Weight: 435.51
Percent Composition: C 60.67%, H 7.64%, N 9.65%, O 22.04%
Properties: White to off-white crystalline powder, mp 98° (dec). [a]D20 -62.51° (c = 1% in ethanol). Soly in water (25°): 0.5 g/100 ml. pKa1 3.3; pKa2 6.4. Partition coefficient (octanol/pH 7.4 buffer, 22°): 0.8.
Melting point: mp 98° (dec)
pKa: pKa1 3.3; pKa2 6.4
Optical Rotation: [a]D20 -62.51° (c = 1% in ethanol)
Log P: Partition coefficient (octanol/pH 7.4 buffer, 22°): 0.8
 
Derivative Type: Diacid
CAS Registry Number: 90139-06-3
Synonyms: Cilazaprilat
Manufacturers' Codes: Ro-31-3113
Molecular Formula: C20H27N3O5
Molecular Weight: 389.45
Percent Composition: C 61.68%, H 6.99%, N 10.79%, O 20.54%
Properties: Crystals from water, mp 242°. [a]D20 -74.7° (c = 0.5 in 1M NaOH).
Melting point: mp 242°
Optical Rotation: [a]D20 -74.7° (c = 0.5 in 1M NaOH)
 
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.