Home > Name List By o > O-(5,6,7,8-tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate China

CAS No 88678-31-3 , O-(5,6,7,8-tetrahydronaphthalen-2-yl)
N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate Search by region : China

  • Name: O-(5,6,7,8-tetrahydronaphthalen-2-yl)
    N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate
  • Synonyms: Liranaftato [INN-Spanish];O-(5,6,7,8-tetrahydronaphthalen-2-yl)
    N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate; 88678-31-3; Liranaftatum [INN-Latin]; Liranaftatum; Liranaftato;Piritetrate; M-732; Zefnart;
  • CAS Registry Number:
  • Density: 1.24g/cm3
  • Refractive index: 1.641
  • Molecular Weight: 328.4286
  • InchiKey: VPHPQNGOVQYUMG-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H20N2O2S/c1-20(16-8-5-9-17(19-16)21-2)18(23)22-15-11-10-13-
    6-3-4-7-14(13)12-15/h5,8-12H,3-4,6-7H2,1-2H3
  • Molecular Formula: C18H20N2O2S
  • Molecular Structure:CAS No:88678-31-3 O-(5,6,7,8-tetrahydronaphthalen-2-yl)<br />N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate

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References of O-(5,6,7,8-tetrahydronaphthalen-2-yl)
N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate
Title: Liranaftate
CAS Registry Number: 88678-31-3
CAS Name: (6-Methoxy-2-pyridinyl)methylcarbamothioic acid O-(5,6,7,8-tetrahydro-2-naphthalenyl) ester
Synonyms: O-5,6,7,8-tetrahydro-2-naphthyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate; piritetrate
Manufacturers' Codes: M-732
Trademarks: Zefnart (Tosoh)
Molecular Formula: C18H20N2O2S
Molecular Weight: 328.43
Percent Composition: C 65.83%, H 6.14%, N 8.53%, O 9.74%, S 9.76%
Literature References: Squalene epoxidase inhibitor. Prepn: BE 897021; T. Takematsu et al., US 4554012 (1983, 1985 both to Toyo Soda Manufacturing Co., Ltd.). Mode of action study: T. Morita et al., J. Med. Vet. Mycol. 27, 17 (1989). Antifungal spectrum: K. Iwata et al., Antimicrob. Agents Chemother. 33, 2118 (1989). Physicochemical properties and stability: H. Awano et al., Iyakuhin Kenkyu 23, 558 (1992).
Properties: White crystalline powder, mp 98.5-99.5°. Soly (ml/g): acetone 10; chloroform 2; dehydrated ethanol 152; dichloromethane 2; ether 21; hexane 233; methanol 175; water >10000. Soly (mg/l): 0.10 (distilled water); 0.07 (buffer pH 1); 0.08 (buffer pH 4); 0.07 (buffer pH 7); 0.08 (buffer pH 11). Sol in benzene, dimethyl sulfoxide, N,N-dimethylformamide.
Melting point: mp 98.5-99.5°
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Thiocarbamates.