Home > Name List By other > [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate China

CAS No 87-00-3 , [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]
2-hydroxy-2-phenylacetate Search by region : China

  • Name: [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]
    2-hydroxy-2-phenylacetate
  • Synonyms: Mandelytropeine; Homotropine; Methylhomatropinum; Homoatropine;87-00-3;[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]
    2-hydroxy-2-phenylacetate; Mandelyltropeine; Homatropin; Homatropine [BAN];
  • CAS Registry Number:
  • Melting Point: 100ºC
  • Flash Point: 197.7 ºC
  • Boiling Point: 403.3 ºC
  • Density: 1.21 g/cm3
  • Safety Statements: A poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx.
  • Hazard Symbols: Moderately toxic by ingestion and subcutaneous routes.
  • Flash Point: 197.7 ºC
  • EINECS: 201-716-8
  • Molecular Weight: 275.34284
  • InchiKey: ZTVIKZXZYLEVOL-DGKWVBSXSA-N
  • InChI: InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-
    2-4-6-11/h2-6,12-15,18H,7-10H2,1H3/t12-,13+,14?,15?
  • Molecular Formula: C16H21NO3
  • Molecular Structure:CAS No:87-00-3 [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]<br />2-hydroxy-2-phenylacetate

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87-00-3 HOMATROPINE

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87-00-3 homatropine

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87-00-3 Benzeneacetic acid, a-hydroxy-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

  • China Beijing Merson Pharmaceutical Co., Ltd [Manufacturers]
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References of [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]
2-hydroxy-2-phenylacetate
Title: Homatropine
CAS Registry Number: 87-00-3
CAS Name: endo-(±)-a-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Synonyms: 1aH,5aH-tropan-3a-ol mandelate; mandelyltropeine; tropine mandelate
Molecular Formula: C16H21NO3
Molecular Weight: 275.34
Percent Composition: C 69.79%, H 7.69%, N 5.09%, O 17.43%
Literature References: Ophthalmic anticholinergic. Prepd from mandelic acid and tropine: Ladenburg, Ann. 217, 82 (1883); Chemnitius, J. Prakt. Chem. 117, 142 (1927). Prepn of D(-)- and L(+)-forms: Werner, Miltenberger, Ann. 631, 163 (1960). Comprehensive description: F. J. Muhtadi et al., Anal. Profiles Drug Subs. 16, 245-290 (1987). Toxicity: R. L. Cahen, K. Tvede, J. Pharmacol. Exp. Ther. 105, 166 (1952).
 
Derivative Type: DL-Form
Properties: Prisms from ether, mp 99-100°. Poisonous! Hygroscopic, but only slightly sol in water; sol in alcohol, benzene, chloroform, ether, acetone, dil acids.
Melting point: mp 99-100°
 
Derivative Type: DL-Hydrobromide
CAS Registry Number: 51-56-9
Trademarks: Homatrisol (Cooper); Bufopto Homatrocel (Softcon)
Molecular Formula: C16H21NO3.HBr
Molecular Weight: 356.25
Percent Composition: C 53.94%, H 6.22%, N 3.93%, O 13.47%, Br 22.43%
Properties: Orthorhombic, bipyramidal prisms from water, mp ~212° (partial decompn). Poisonous! One gram dissolves in 6 ml water, 40 ml alcohol (12 ml at 60°), 420 ml chloroform. Insol in ether. pH (1% aq soln): 5.4.
Melting point: mp ~212° (partial decompn)
 
Derivative Type: DL-Hydrochloride
Molecular Formula: C16H21NO3.HCl
Molecular Weight: 311.80
Percent Composition: C 61.63%, H 7.11%, N 4.49%, O 15.39%, Cl 11.37%
Properties: Prisms from water, mp 217-220° (dec). Poisonous! Freely sol in water, alcohol. pH (1% aq soln): 5.4.
Melting point: mp 217-220° (dec)
 
Derivative Type: DL-Methylbromide
CAS Registry Number: 80-49-9
Trademarks: Arkitropin; Homapin (Mission Pharmacal); Malcotran (Fisons); Mesopin (Endo); Novatrin (Ayerst); Novatropine; Sethyl
Molecular Formula: C16H21NO3.CH3Br
Molecular Weight: 370.28
Percent Composition: C 55.14%, H 6.53%, N 3.78%, O 12.96%, Br 21.58%
Properties: Minute needles from alc + ether, mp 191-192° (slight dec). Poisonous! Freely sol in water, dil alc; slightly sol in abs alc. Insol in ether. pH (1% aq soln) 5.9; pH (10% aq soln) 4.5. LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede).
Melting point: mp 191-192° (slight dec)
Toxicity data: LD50 in mice (mg/kg): 1400 orally, 60 i.p. (Cahen, Tvede)
 
Therap-Cat: Mydriatic.
Keywords: Antimuscarinic; Mydriatic.