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CAS No 84845-57-8 , ritipenem

  • Name: ritipenem
  • Synonyms: Ritipenem;ritipenem;RITIPENEM ACOXIL;
  • CAS Registry Number:
  • Flash Point: 352.6°C
  • Boiling Point: 659.4°C at 760 mmHg
  • Density: 1.71g/cm3
  • Refractive index: 1.691
  • Flash Point: 352.6°C
  • Molecular Weight: 0
  • InChI: InChI=1S/C10H12N2O6S/c1-3(13)5-7(14)12-6(9(15)16)4(19-8(5)12)2-18-10(11)17/h3,5,8,13H,2H2,1H3,(H2,11,17)(H,15,16)/t3-,5+,8-/m1/s1
  • Molecular Formula: C10H12N2O6S
  • Molecular Structure:CAS No:84845-57-8 ritipenem
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84845-57-8 Ritipenem

  • Ritipenem, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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84845-57-8 Ritipenem

  • Ritipenem
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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84845-57-8 RITIPENEM

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of ritipenem
Title: Ritipenem
CAS Registry Number: 84845-57-8
CAS Name: (5R,6S)-3-[[(Aminocarbonyl)oxy]methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Synonyms: (5R,6S,8R)-6a-hydroxyethyl-2-carbamoyloxymethyl-2-penem-3-carboxylic acid; (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-(hydroxymethyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-carbamate
Molecular Formula: C10H12N2O6S
Molecular Weight: 288.28
Percent Composition: C 41.66%, H 4.20%, N 9.72%, O 33.30%, S 11.12%
Literature References: Prepn: M. Alpegiani et al., DE 3245270; M. Foglio et al., US 4482565 (1983, 1984 both to Carlo Erba). Synthesis: G. Franceschi et al., J. Antibiot. 36, 938 (1983). Total synthesis: W. Cabri et al., Tetrahedron Lett. 34, 3491 (1993). Toxicity study: M. Brughera et al., J. Antimicrob. Chemother. 23, Suppl. C, 129 (1989). Series of articles on synthesis, in vitro activity, metabolism: ibid., 1-204 (1989). Clinical pharmacokinetics of acid and ester forms: S. R. Norrby et al., ibid. 25, 371 (1990); A. M. Lovering et al., ibid. 29, 179 (1992). HPLC determn in serum and urine: R. Mendez et al., J. Chromatogr. 579, 115 (1992).
 
Derivative Type: Sodium salt
CAS Registry Number: 84845-58-9
Manufacturers' Codes: FCE-22101
Molecular Formula: C10H11N2NaO6S
Molecular Weight: 310.26
Percent Composition: C 38.71%, H 3.57%, N 9.03%, Na 7.41%, O 30.94%, S 10.33%
Properties: [a]D20 +140°. uv max (H2O): 258, 306 nm (e 4150, 6030). LD50 in male, female mice, male, female rats (mg/kg): 3872, 4393, 2000, 2201 i.v. (Brughera).
Optical Rotation: [a]D20 +140°
Absorption maximum: uv max (H2O): 258, 306 nm (e 4150, 6030)
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 3872, 4393, 2000, 2201 i.v. (Brughera)
 
Derivative Type: Acetoxymethyl ester
CAS Registry Number: 87238-52-6
Synonyms: Ritipenem acoxil
Manufacturers' Codes: FCE-22891
Molecular Formula: C13H16N2O8S
Molecular Weight: 360.34
Percent Composition: C 43.33%, H 4.48%, N 7.77%, O 35.52%, S 8.90%
Properties: LD50 in male, female mice, male, female rats (mg/kg): 4363, 6167, >5000, >5000 orally (Brughera).
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 4363, 6167, >5000, >5000 orally (Brughera)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Penems.