Home > Name List By 7 > 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1, 4-benzodiazepin-2-one

CAS No 846-49-1 , 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,
4-benzodiazepin-2-one

  • Name: 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,
    4-benzodiazepin-2-one
  • Synonyms: o-Chloroxazepam;7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,
    4-benzodiazepin-2-one; o-Chlorooxazepam; Idalprem; Bonatranquan; Aplacassee;Ativan; Temesta; Delormetazepam; Tavor;
  • CAS Registry Number:
  • Transport: UN 1230 3/PG 2
  • Melting Point: 166-168 ºC
  • Flash Point: 276.7 ºC
  • Boiling Point: 533.8 ºC at 760 mmHg
  • Density: 1.52 g/cm3
  • Water Solubility: Soluble to 100 mM in DMSO and to 40 mM in Ethanol
  • Safety Statements: 36/37-45-16
  • Hazard Symbols: Xn: Harmful;F: Flammable;T: Toxic;
  • Flash Point: 276.7 ºC
  • EINECS: 212-687-6
  • Molecular Weight: 321.1581
  • InchiKey: DIWRORZWFLOCLC-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-
    1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
  • Risk Statements: R63
  • Molecular Formula: C15H10Cl2N2O2
  • Molecular Structure:CAS No:846-49-1 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,<br />4-benzodiazepin-2-one
Search by region :

Select to

846-49-1 Lorazepam

  • Product Lorazepam CAS NO 846-49-1 Molecular Formula C15H10Cl2N2O2 Molecular Weight 321.16 Description Almost white crystalline powder Package 25KG/drums Application schizophrenia
  • China Jinan Jianfeng Chemical Co.Ltd [Manufacturer]
  • Tel: 86-531-88110457
  • Fax: --
  • Address: NO9. Hua Neng Road, Jinan, China Jinan,ShandongChina

846-49-1 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
Contact Supplier

846-49-1 Lorazepam

Contact Supplier

846-49-1 Lorazepam

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
Contact Supplier

846-49-1 LORAZEPAM

  • Norway Chiron AS [Manufacturer]
  • Tel: +47 73 87 44 90
  • Fax: +47 73 87 44 99
  • Address: Chiron AS
    Stiklestadveien 1
    N-7041 Trondheim
    Norway ,Norway
Contact Supplier

846-49-1 LORAZEPAM

  • India JAI RADHE SALES []
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. ,India
Contact Supplier

846-49-1 Ativan

  • India Manus Aktteva []
  • Tel: +91-(79)-65123395
  • Fax: +91-(79)-26463395
  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, ,India
Contact Supplier

846-49-1 2548.15-100-ME LORAZEPAM

  • Germany Campro Scientific GmbH [Manufacturer]
  • Tel: +49.(0)30.629.01.89.0 (Germany)/ +31.(0)318.529.437 (Netherlands)
  • Fax: +49.(0)30.629.01.89.89
    +31.(0)318.542.181
  • Address: Campro Scientific GmbH
    Postfach 36 20 65
    D-10972 Berlin
    Germany
    Tel. +49.(0)30.629.01.89.0
    Fax +49.(0)30.629.01.89.89
    info@campro.eu ,Germany
Contact Supplier

846-49-1 Lorazepam

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
Contact Supplier

846-49-1 LORAZEPAM

  • China ORICHEM INTERNATIONAL LTD. [, Manufacturer, Trading Company]
  • Tel: 86-0571-85270505
  • Fax: 86-0571-85270303
  • Address: FLAT E,16/F,1 HUAZHE PLAZA,HANGZHOU, ,China
Contact Supplier

Select to

References of 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,
4-benzodiazepin-2-one
Title: Lorazepam
CAS Registry Number: 846-49-1
CAS Name: 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
Manufacturers' Codes: Wy-4036
Trademarks: Ativan (Wyeth); Emotival (Armstrong); Lorax (Wyeth); Lorsilan (Belupo); Pro Dorm (Synthelabo); Psicopax (Schering); Punktyl (Krewel); Quait (SIT); Sedatival (Raffo); Sedazin (Lagap); Somagerol (Brenner-Efeka); Tavor (Wyeth); Temesta (Wyeth); Wypax (Yamanouchi)
Molecular Formula: C15H10Cl2N2O2
Molecular Weight: 321.16
Percent Composition: C 56.10%, H 3.14%, Cl 22.08%, N 8.72%, O 9.96%
Literature References: Prepn: S. C. Bell, BE 621819; idem, US 3296249 (1963, 1967 both to Am. Home Prod.); and structure-activity study: idem et al., J. Med. Chem. 11, 457 (1968). Determn by HPLC: I. Jane, A. McKinnon, J. Chromatogr. 323, 191 (1985). Series of articles on pharmacology, metabolism, clinical studies: Arzneim.-Forsch. 21, 1047-1102 (1971). Toxicity study: G. Owen et al., ibid. 1065. Comprehensive description: J. G. Rutgers, C. M. Shearer, Anal. Profiles Drug Subs. 9, 397-426 (1980). Review of clinical pharmacology and therapeutic use: B. Ameer, D. J. Greenblatt, Drugs 21, 161-200 (1981). Clinical trial to prevent recurrent alcohol-related seizures: G. D'Onofrio et al., N. Engl. J. Med. 340, 915 (1999).
Properties: Crystals, mp 166-168°. uv max (methanol): 229 nm, (1N NaOH): 233 nm, (1N HCl): 237 nm. Soly (mg/ml): water 0.08, chloroform 3, alcohol 14, propylene glycol 16, ethyl acetate 30. pK1 1.3; pK2 11.5. LD50 in mice, rats (mg/kg): 3178, >5000 orally (Owen).
Melting point: mp 166-168°
pKa: pK1 1.3; pK2 11.5
Absorption maximum: uv max (methanol): 229 nm, (1N NaOH): 233 nm, (1N HCl): 237 nm
Toxicity data: LD50 in mice, rats (mg/kg): 3178, >5000 orally (Owen)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic; anticonvulsant.
Keywords: Anxiolytic; Benzodiazepine Derivatives; Anticonvulsant.