Home > Name List By 4 > 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine

CAS No 83-89-6 , 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine

  • Name: 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
  • Synonyms: Erion; atabrine; Haffkinine; Acriquine; Antimalarina; quinacrine; Acrinamine; Quinactine;4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;mepacrine; Akrichin;
  • CAS Registry Number:
  • Melting Point: 247-250 °C
  • Density: 1.156 g/cm3
  • Safety Statements: Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. Experimental reproductive effects. Has been implicated in aplastic anemia. When heated to decomposition, it emits very toxic fumes of Cl− and NOx.
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 201-508-7
  • Molecular Weight: 399.9568
  • InchiKey: GPKJTRJOBQGKQK-UHFFFAOYSA-N
  • InChI: InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22
    (19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,
    26)
  • Risk Statements: 36/37/38-22
  • Molecular Formula: C23H30ClN3O
  • Molecular Structure:CAS No:83-89-6 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine

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References of 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
Title: Quinacrine
CAS Registry Number: 83-89-6
CAS Name: N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine
Synonyms: 6-chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxyacridine; 3-chloro-7-methoxy-9-(1-methyl-4-diethyl aminobutylamino)acridine; 2-chloro-5-(w-diethylamino-a-methylbutylamino)-7-methoxyacridine; mepacrine
Molecular Formula: C23H30ClN3O
Molecular Weight: 399.96
Percent Composition: C 69.07%, H 7.56%, Cl 8.86%, N 10.51%, O 4.00%
Literature References: Prepd by condensing 1-diethylamino-4-aminopentane with 3,9-dichloro-7-methoxyacridine: F. Mietzsch, H. Mauss, DE 553072; DE 571499 (1934); eidem, US 2113357 (1938 to Winthrop Chemical); cf. Drosdov, Cherutzov, J. Gen. Chem. USSR 5, 1576, 1736 (1935); 8, 1192 (1938); Magidson, Grigorovskii, Khim. Farm. Prom. 1933, 187; Jensch, Eisleb, US 1782727 (1930); Schulemann et al., US 1889704 (1932). Review of quinacrine and other acridines: A. O. Wolfe in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 203-233.
 
Derivative Type: Dihydrochloride dihydrate
CAS Registry Number: 6151-30-0
Manufacturers' Codes: RP-866; SN-390
Trademarks: Atabrine hydrochloride (Sanofi Winthrop)
Molecular Formula: C23H30ClN3O.2HCl.2H2O
Molecular Weight: 508.91
Percent Composition: C 54.28%, H 7.13%, Cl 20.90%, N 8.26%, O 9.43%
Properties: Bitter, bright yellow crystals. Dec 248-250° (mp poorly discernible). One gram dissolves in ~35 ml water. Much more sol in hot water. Slightly sol in ethanol, somewhat more sol in methanol. Insol in ether, benzene, acetone. pH of a 1% aq soln ~4.5. Under uv light the yellow aq solns exhibit a vivid fluorescence which is detectable in a dilution of 1:5,000,000.
 
Derivative Type: Methanesulfonate monohydrate
CAS Registry Number: 6598-46-5
Molecular Formula: C25H38ClN3O7S2.H2O
Molecular Weight: 610.18
Percent Composition: C 49.21%, H 6.61%, Cl 5.81%, N 6.89%, O 20.98%, S 10.51%
Properties: Bitter, bright yellow crystals. One part dissolves in 3 parts water at 15.5°, in 36 parts 95% alcohol at 15.5°. pH of 2.0% w/v soln in water 3.0-5.0.
 
Therap-Cat: Anthelmintic (Cestodes); antimalarial.
Therap-Cat-Vet: Antiprotozoal, teniacide.
Keywords: Anthelmintic (Cestodes); Antimalarial.