Home > Name List By c > Combretastatin

CAS No 82855-09-2 , Combretastatin

  • Name: Combretastatin
  • CAS Registry Number:
  • Flash Point: 247.278°C
  • Boiling Point: 485.262°C at 760 mmHg
  • Density: 1.213g/cm3
  • Refractive index: 1.57
  • Flash Point: 247.278°C
  • Molecular Weight: 0
  • InChI: InChI=1S/C18H22O6/c1-21-15-6-5-11(8-14(15)20)7-13(19)12-9-16(22-2)18(24-4)17(10-12)23-3/h5-6,8-10,13,19-20H,7H2,1-4H3/t13-/m1/s1
  • Molecular Formula: C18H22O6
  • Molecular Structure:CAS No:82855-09-2 Combretastatin

Related products

Select to

82855-09-2 Combretastatin

  • Combretastatin, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
Contact Supplier

82855-09-2 COMBRETASTATIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
Contact Supplier

Select to

1/1
References of Combretastatin
Title: Combretastatins
Literature References: A group of compounds isolated from the bark and stem wood of the South African bushwillow tree, Combretum caffrum, which inhibit tubulin polmerization. The most active are combretastatins A-2 and A-4. Used in folk medicine, extracts have shown antileukemic properties. Isoln: G. R. Pettit et al., Can. J. Chem. 60, 1374 (1982); of A-2: G. R. Pettit, S. B. Singh, ibid. 65, 2390 (1987); of A-4: idem et al., Experientia 45, 209 (1989). Enantioselective synthesis: A. Ramacciotti et al., Tetrahedron: Asymmetry 7, 1101 (1996). Mechanism of action study: C. M. Lin et al., Biochemistry 28, 6984 (1989). Antineoplastic activity of A-4: A. A. E. El-Zayat et al., Anti-Cancer Drugs 4, 19 (1993); inhibition of tumor vascularization: G. G. Dark et al., Cancer Res. 57, 1829 (1997). Review of structure-activity of combretastatins, podophyllotoxin, q.v. and steganacin: D. L. Sackett, Pharmacol. Ther. 59, 163-228 (1993).
 
Derivative Type: Combretastatin
CAS Registry Number: 82855-09-2
CAS Name: (R)-3-Hydroxy-4-methoxy-a-(3,4,5-trimethoxyphenyl)benzeneethanol
Synonyms: (-)-combretastatin
Molecular Formula: C18H22O6
Molecular Weight: 334.36
Percent Composition: C 64.66%, H 6.63%, O 28.71%
Properties: Needles from acetone-hexane, mp 130-131°. [a]D26 -8.51° (c = 1.41 in chloroform). uv max (methanol): 212, 228 (shoulder), 279, 287 nm (shoulder) (log e 4.33, 4.11, 3.47, 3.36). d 1.33.
Melting point: mp 130-131°
Optical Rotation: [a]D26 -8.51° (c = 1.41 in chloroform)
Absorption maximum: uv max (methanol): 212, 228 (shoulder), 279, 287 nm (shoulder) (log e 4.33, 4.11, 3.47, 3.36)
Density: d 1.33
 
Derivative Type: Combretastatin A-4
CAS Registry Number: 117048-59-6
CAS Name: (Z)-2-Methoxy-5-[2-(3,4,5,-trimethoxyphenyl)ethenyl]phenol
Synonyms: 3,4,5-trimethoxy-3￠-hydroxy-4￠-methoxy-(Z)-stilbene; CS-A4
Molecular Formula: C18H20O5
Molecular Weight: 316.35
Percent Composition: C 68.34%, H 6.37%, O 25.29%
Properties: Fine crystals from ethylacetate-hexane, mp 84.5-85.5°.
Melting point: mp 84.5-85.5°