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CAS No 82034-46-6 , Loteprednol etabonate Search by region : China

  • Name: Loteprednol etabonate
  • Synonyms: Loteprednol etabonate;Chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate;
  • CAS Registry Number:
  • Melting Point: 220.5-223.5
  • Density: 1.31 g/cm 1.31 g/cm3
  • Refractive index: 1.57
  • Molecular Weight: 466.96
  • InChI: InChI=1/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16?,17?,18-,19?,22-,23-,24-/m0/s1
  • Molecular Formula: C24H31ClO7
  • Molecular Structure:CAS No:82034-46-6 Loteprednol etabonate

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References of Loteprednol etabonate
Title: Loteprednol Etabonate
CAS Registry Number: 82034-46-6
CAS Name: (11b,17a)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid chloromethyl ester
Synonyms: chloromethyl 17a-ethoxycarbonyloxy-11b-hydroxyandrosta-1,4-diene-3-one-17b-carboxylate; 17a-ethoxycarbonyloxy-D￠-cortienic acid chloromethyl ester
Manufacturers' Codes: CDDD-5604; HGP-1; P-5604
Trademarks: Alrex (Bausch & Lomb); Lotemax (Bausch & Lomb)
Molecular Formula: C24H31ClO7
Molecular Weight: 466.95
Percent Composition: C 61.73%, H 6.69%, Cl 7.59%, O 23.98%
Literature References: Ophthalmic corticosteroid. Prepn: N. S. Bodor, BE 889563 (1981 to Otsuka); idem, US 4996335 (1991). Physicochemical properties: M. Alberth et al., J. Biopharm. Sci. 2, 115 (1991). HPLC determn in plasma and urine: G. Hochhaus et al., J. Pharm. Sci. 81, 1210 (1992). NMR structural studies: S. Rachwal et al., Steroids 61, 524 (1996); idem et al., ibid. 63, 193 (1998). Metabolism and transdermal permeability: N. Bodor et al., Pharm. Res. 9, 1275 (1992). Evaluation of effect on intraocular pressure: J. D. Bartlett et al., J. Ocul. Pharmacol. 9, 157 (1993). Clinical trial in keratoconjunctivitis sicca: S. C. Pflugfelder et al., Am. J. Ophthalmol. 138, 444 (2004). Review of ophthalmic clinical studies: J. F. Howes, Pharmazie 55, 178-183 (2000).
Properties: Crystals from THF + hexane, mp 220.5-223.5°. Soly at 25° (mg/ml): 0.0005 in water; 0.037 in 50% propylene glycol + water. Lipophilicity (log K): 3.04.
Melting point: mp 220.5-223.5°
Therap-Cat: Anti-inflammatory (topical).
Keywords: Glucocorticoid.