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CAS No 82-02-0 , 4,9-dimethoxy-7-methylfuro[3,2-g]chromen-5-one Search by region : China

  • Name: 4,9-dimethoxy-7-methylfuro[3,2-g]chromen-5-one
  • Synonyms: Rykellin; Kelourin; Ammispasmin;Visammin; Amicardine; Coronin; Methafrone; Corafurone;4,9-dimethoxy-7-methylfuro[3,2-g]chromen-5-one; Ammivisnagen;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 3
  • Density: 1.301 g/cm3
  • Refractive index: 1.595
  • Safety Statements: 36/37/39-45
  • Hazard Symbols: T: Toxic;
  • EINECS: 201-392-8
  • Molecular Weight: 260.24208
  • InchiKey: HSMPDPBYAYSOBC-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H12O5/c1-7-6-9(15)10-11(16-2)8-4-5-18-12(8)14(17-3)13(10)19-
    7/h4-6H,1-3H3
  • Risk Statements: 25-38
  • Molecular Formula: C14H12O5
  • Molecular Structure:CAS No:82-02-0 4,9-dimethoxy-7-methylfuro[3,2-g]chromen-5-one

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82-02-0 KHELLIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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82-02-0 5H-Furo[3,2-g][1]benzopyran-5-one,4,9-dimethoxy-7-methyl-

  • China BioBioPha Co., Ltd. [Manufacturer]
  • Tel: +86-871-5217109
  • Fax: +86-871-5217109
  • Address: 132 Lanhei Road, Kunming Institute of Botany, Chinese Academy of Sciences null,nullChina
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References of 4,9-dimethoxy-7-methylfuro[3,2-g]chromen-5-one
Title: Khellin
CAS Registry Number: 82-02-0
CAS Name: 4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one
Synonyms: 5,8-dimethoxy-2-methyl-4¢,5¢-furo-6,7-chromone; 5,8-dimethoxy-2-methyl-6,7-furanochromone; 4,9-dimethoxy-7-methyl-5-oxofuro[3,2-g]-1,2-chromene; 4,9-dimethoxy-7-methyl-5-oxo-1,8-dioxabenz[f]indene; visammin
Trademarks: Ammivin; Lynamine (Memphis); Vasokellina (Angelini)
Molecular Formula: C14H12O5
Molecular Weight: 260.24
Percent Composition: C 64.61%, H 4.65%, O 30.74%
Literature References: Found in seeds of Ammi visnaga Lam., Umbelliferae; one of the active principles of the Egyptian traditional medicine known as "khella." See also: visnadine, visnagin. Isoln and structure: Sp?th, Gruber, Ber. 71, 106 (1938). Synthesis: Baxter et al., J. Chem. Soc. 1949, S 30; Gardner et al., J. Org. Chem. 15, 841 (1950); Sch?nberg, Sina, J. Am. Chem. Soc. 72, 1611, 3396 (1950); M. W. Reed, H. W. Moore, J. Org. Chem. 53, 4166 (1988). Crystal structure: J. P. Beale, Cryst. Struct. Commun. 2, 125 (1973). Toxicity data: E. Busch et al., Arzneim.-Forsch. 11, 915 (1961). GC determn in serum: A. S. Carlin et al., J. Chromatogr. 614, 324 (1993). Clinical evaluation in vitiligo: B. Ortel et al., J. Am. Acad. Dermatol. 18, 693 (1988). Comprehensive description: M. A. Hassan, M. U. Zubai, Anal. Profiles Drug Subs. 9, 371-396 (1980).
Properties: Crystals from methanol. Bitter taste. mp 154-155°. bp0.05 180-200°. uv max (alc): 250, 338 nm (E1%1cm 1600, 200). Soly in g/100 ml at 25°: water 0.025; acetone 3.0; methanol 2.6; isopropanol 1.25; ether 0.5. Much more sol in hot water and hot methanol. LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch).
Melting point: mp 154-155°
Boiling point: bp0.05 180-200°
Absorption maximum: uv max (alc): 250, 338 nm (E1%1cm 1600, 200)
Toxicity data: LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch)
Therap-Cat: Vasodilator (coronary). Photosensitizer in treatment of vitiligo.
Keywords: Vasodilator (Coronary).