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CAS No 81486-22-8 , [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl]
nitrate Search by region : India

  • Name: [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl]
    nitrate
  • Synonyms: K-351; Nipradolol;Hypadil; 81486-22-8; K 351; BRN 3566879; Nipradilolum [Latin]; nipradilol(jan); CCRIS 2515;[8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl]
    nitrate;
  • CAS Registry Number:
  • Flash Point: 256.2°C
  • Boiling Point: 500°C at 760 mmHg
  • Density: 1.27g/cm3
  • Refractive index: 1.561
  • Safety Statements: Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also NITRATES.
  • Flash Point: 256.2°C
  • Molecular Weight: 326.34498
  • InchiKey: OMCPLEZZPVJJIS-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H22N2O6/c1-10(2)16-7-12(18)8-21-14-5-3-4-11-6-13(23-17(19)
    20)9-22-15(11)14/h3-5,10,12-13,16,18H,6-9H2,1-2H3
  • Molecular Formula: C15H22N2O6
  • Molecular Structure:CAS No:81486-22-8 [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl]<br />nitrate

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References of [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl]
nitrate
Title: Nipradilol
CAS Registry Number: 81486-22-8
CAS Name: 3,4-Dihydro-8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2H-1-benzopyran-3-ol 3-nitrate
Synonyms: 3,4-dihydro-8-(2-hydroxy-3-isopropylamino)propoxy-3-nitroxy-2H-1-benzopyran; 8-[2-hydroxy-3-(isopropylamino)propoxy]-3-chromanol 3-nitrate; nipradolol
Manufacturers' Codes: K-351
Trademarks: Hypadil (Kowa)
Molecular Formula: C15H22N2O6
Molecular Weight: 326.34
Percent Composition: C 55.21%, H 6.79%, N 8.58%, O 29.42%
Literature References: b-Adrenergic blocker with vasodilating activity. Prepn: M. Shiratsuchi et al., EP 42299; eidem, US 4394382 (1981, 1983 both to Kowa). Synthesis: M. Shiratsuchi et al., Chem. Pharm. Bull. 35, 632 (1987). Resolution of isomers: M. Shiratsuchi et al., EP 154511; eidem, US 4727085 (1985, 1988 both to Kowa). Synthesis and activity of isomers: M. Shiratsuchi et al., Chem. Pharm. Bull. 35, 3691 (1987). Pharmacology: Y. Uchida et al., Arch. Int. Pharmacodyn. 262, 132 (1983). Hemodynamic effects in dogs: H. Hisa et al., ibid. 271, 169 (1984). Effects on cardiac function in dogs: M. Sakanashi et al., ibid. 274, 47 (1985); M. Fujii et al., Jpn. Heart J. 27, 233 (1986). Pharmacokinetics and metabolism in rats: S. Kabuto et al., Arzneim.-Forsch. 35, 1674 (1985); H. Kimata et al., ibid. 1680. Metabolic fate in dog and man: M. Yoshimura et al., Chem. Pharm. Bull. 33, 3456 (1985). Clinical evaluation in angina: H. Kishida et al., Jpn. Heart J. 29, 309 (1988).
Properties: Colorless needles, mp 107-116° (Shiratsuchi, 1983); also reported as mp 110-122° (Shiratsuchi, 1987). LD50 i.v. in mice, rats: 74.0, 73.0 mg/kg; orally in mice: 540 mg/kg (Shiratsuchi, 1988).
Melting point: mp 107-116° (Shiratsuchi, 1983); mp 110-122° (Shiratsuchi, 1987)
Toxicity data: LD50 i.v. in mice, rats: 74.0, 73.0 mg/kg; orally in mice: 540 mg/kg (Shiratsuchi, 1988)
Therap-Cat: Antianginal; antihypertensive.
Keywords: ?Adrenergic Blocker; Antianginal; Antihypertensive; Aryloxypropanolamine Derivatives.