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CAS No 80214-83-1 , Roxithromycin

  • Name: Roxithromycin
  • Synonyms: Roxithromycin;Roxythromycin;5-(3,4,6-Trideoxy-3-dimethylamino-beta-D-xylo-hexopyranosyloxy)-3-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-6,11,12-trihydroxy-9-(2-methoxyethoxy)methoxyimino-2,4,6,8,10,12-hexamethylpentadecan-13-olide; 5-(3,4,6-trideoxy-3-dimethylamino-beta-d-xylo-hexopyranosyloxy)-3-(2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyloxy)-6,11,12-trihydroxy-9-(2-methoxyethoxy)methoxyimino-2,4,6,8,10,12-hexamethylpentadecan-13-olide;
  • CAS Registry Number:
  • Transport: MAC
  • Melting Point: 115- 120 C
  • Density: 1.25g/cm3
  • Refractive index: 1.535
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 837.05
  • InChI: InChI=1/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+/t22-,23?,24+,25+,26-,27?,28?,29-,30?,32?,33+,34-,35?,36-,38?,39-,40?,41-/m1/s1
  • Risk Statements: R22
  • Molecular Formula: C41H76N2O15
  • Molecular Structure:CAS No:80214-83-1 Roxithromycin

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References of Roxithromycin
Title: Roxithromycin
CAS Registry Number: 80214-83-1
CAS Name: Erythromycin 9-[O-[(2-methoxyethoxy)methyl]oxime]
Synonyms: oxacyclotetradecane erythromycin deriv; 9-(2￠,5￠-dioxahexyloxyimino)erythromycin
Manufacturers' Codes: RU-28965; RU-965
Trademarks: Assoral (Glaxo); Claramid (Jouveinal); Forilin (Novo); Overal (Lusofarmaco); Rossitrol (Corvi); Rotramin (Glaxo-Allen); Rulid (Hoechst); Surlid (HMR)
Molecular Formula: C41H76N2O15
Molecular Weight: 837.05
Percent Composition: C 58.83%, H 9.15%, N 3.35%, O 28.67%
Literature References: Semisynthetic erythromycin derivative. Prepn: S. Gouin d￠Ambrieres et al., FR 2473525; eidem, US 4349545 (1981, 1982 both to Roussel-UCLAF). In vitro antibacterial spectrum: R. N. Jones et al., Antimicrob. Agents Chemother. 24, 209 (1983); Y. J. Drabu et al., Drugs Exp. Clin. Res. 13, 201 (1987). Antiprotozoal activity in mice: B. J. Luft, Eur. J. Clin. Microbiol. 6, 479 (1987); H. R. Chang, J.-C. R. Pechere, Antimicrob. Agents Chemother. 31, 1147 (1987). Pharmacokinetics: R. Wise et al., ibid. 1051. Bioassay in biological fluids: A. L. Barry, R. R. Packer, Eur. J. Clin. Microbiol. 5, 536 (1986). Clinical evaluations in respiratory tract infections: J. M. Lachat et al., Schweiz. Med. Wochenschr. 116, 1739 (1986); C. Grassi et al., Chemioterapia 6, 41 (1987). Series of articles on antimicrobial activity, pharmacokinetics and clinical efficacy: J. Antimicrob. Chemother. 20, Suppl. B, 1-185 (1987).
Properties: [a]D25 -77.5 ±2° (c = 0.45 in chloroform).
Optical Rotation: [a]D25 -77.5 ±2° (c = 0.45 in chloroform)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.