Home > Name List By a > Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1...

CAS No 801-52-5 , Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)-

  • Name: Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)-
  • Synonyms: NCI 56410;Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)-; NSC 56410; N-Methylmitomycin C;Porfiromycine; U 14743;Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethyl-,carbamate (ester) (8CI); ENT 50825; Porfiromycin; Methylmitomycin; Regamycin; Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,[1aS-(1aa,8b,8aa,8ba)]-; Methyl mitomycinC;
  • CAS Registry Number:
  • Flash Point: 293°C
  • Boiling Point: 560.9°C at 760 mmHg
  • Density: 1.52g/cm3
  • Refractive index: 1.672
  • Safety Statements: Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Human systemic effects by intravenous route: blood effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 293°C
  • Molecular Weight: 0
  • InChI: InChI=1/C16H20N4O5/c1-6-10(17)13(22)9-7(5-25-15(18)23)16(24-3)14-8(19(14)2)4-20(16)11(9)12(6)21/h7-8,14H,4-5,17H2,1-3H3,(H2,18,23)
  • Molecular Formula: C16H20 N4 O5
  • Molecular Structure:CAS No:801-52-5 Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)-

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References of Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)-
Title: Porfiromycin
CAS Registry Number: 801-52-5
CAS Name: [1aS-(1aa,8b,8aa,8ba)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethylazirino[2￠,3￠:3,4]pyrrolo[1,2-a]indole-4,7-dione
Synonyms: N-methylmitomycin C
Manufacturers' Codes: U-14743
Molecular Formula: C16H20N4O5
Molecular Weight: 348.35
Percent Composition: C 55.17%, H 5.79%, N 16.08%, O 22.96%
Literature References: Antibiotic substance isolated from a Streptomyces ardus fermentation broth: Herr et al., Antimicrob. Agents Annu. 1960, 23. Isoln from S. verticillatus and structure: Webb et al., J. Am. Chem. Soc. 84, 3185, 3187 (1962). Production process: Bohonos et al., US 3219530 (1965 to Am. Cyanamid). Synthesis of (±)-form: F. Nakatsubo et al., J. Am. Chem. Soc. 99, 8115 (1977). For stereochemistry and other synthetic studies, see Mitomycins.
Properties: Dark purple triclinic crystals, dec 201-201.5°. [a]D25 +275 ±55° (c = 0.1% in methanol); [a]D25 +242 ±100° (c = 0.045% in methanol). uv max (methanol): 217, 360, 555 nm (e 24600, 23000, 209). Slightly sol in water, moderately sol in polar organic solvents. Practically insol in hydrocarbon solvents.
Optical Rotation: [a]D25 +275 ±55° (c = 0.1% in methanol); [a]D25 +242 ±100° (c = 0.045% in methanol)
Absorption maximum: uv max (methanol): 217, 360, 555 nm (e 24600, 23000, 209)
Therap-Cat: Antibacterial; antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs.