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CAS No 79-17-4 , 2-aminoguanidine

  • Name: 2-aminoguanidine
  • Synonyms: Hydrazinecarboximidamide; Monoaminoguanidine;aminoguanidine; Guanyl hydrazine; Pimagedine; guanylhydrazine; Imino semicarbazide;2-aminoguanidine; Aminate base;
  • CAS Registry Number:
  • Flash Point: 111.9°C
  • Boiling Point: 261.4°C at 760 mmHg
  • Density: 1.72g/cm3
  • Refractive index: 1.666
  • Safety Statements: Moderately toxic by subcutaneous route. See also AMINES. All of the oxoacid salts are potentially explosive. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 111.9°C
  • EINECS: 201-183-1
  • Molecular Weight: 74.08514
  • InchiKey: HAMNKKUPIHEESI-UHFFFAOYSA-N
  • InChI: InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5)
  • Molecular Formula: CH6N4
  • Molecular Structure:CAS No:79-17-4 2-aminoguanidine

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79-17-4 Hydrazinecarboximidamide

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79-17-4 AMINOGUANIDINE

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References of 2-aminoguanidine
Title: Aminoguanidine
CAS Registry Number: 79-17-4
CAS Name: Hydrazinecarboximidamide
Synonyms: guanylhydrazine; pimagedine
Molecular Formula: CH6N4
Molecular Weight: 74.09
Percent Composition: C 16.21%, H 8.16%, N 75.62%
Literature References: Nucleophilic hydrazine; inhibits the formation of advanced glycosylation end products (AGEs) that have been implicated in the etiology of diabetic complications. Prepn: J. Thiele, Ann. 270, 1 (1892); G. B. L. Smith, E. Anzelmi, J. Am. Chem. Soc. 57, 2730 (1935). Review of chemistry of aminoguanidine and related compounds: E. Lieber, G. B. L. Smith, Chem. Rev. 25, 213-271 (1939); of preparative methods: F. Kurzer, L. E. A. Godfrey, Chem. Ind. (London) 1962, 1584-1595. Prevention of glucose-derived aortic collagen cross-linking in diabetic rats: M. Brownlee et al., Science 232, 1629 (1986). Mechanism of action study: D. Edelstein, M. Brownlee, Diabetes 41, 26 (1992). Review of therapeutic potential: B. H. R. Wolffenbuttel, M. S. P. Huijberts, Neth. J. Med. 42, 205-208 (1993).
Properties: Crystals. Sol in water, alc. Practically insol in ether. Aq soln is strongly alkaline and reddens on standing in air; ammonia is evolved on heating.
 
Derivative Type: Hydrochloride
CAS Registry Number: 1937-19-5
Manufacturers' Codes: GER-11
Molecular Formula: CH6N4.HCl
Molecular Weight: 110.55
Percent Composition: C 10.86%, H 6.38%, N 50.68%, Cl 32.07%
Properties: Large prisms from dil alc, mp 163°. Very sol in water; sol in alc. Practically insol in ether.
Melting point: mp 163°
 
Therap-Cat: In prevention and treatment of chronic diabetic complications.