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CAS No 77671-31-9 , 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one

  • Name: 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one
  • Synonyms: MDL-17043; Enoximona;4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one; 77671-31-9; Fenoximone; Enoximonum [Latin]; Perfane; Enoximona [Spanish]; Enoximonum;Perfan;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 255-258 ºC
  • Density: 1.33
  • Refractive index: 1.645
  • Molecular Weight: 248.30088
  • InchiKey: ZJKNESGOIKRXQY-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-
    6H,1-2H3,(H2,13,14,16)
  • Molecular Formula: C12H12N2O2S
  • Molecular Structure:CAS No:77671-31-9 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one

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77671-31-9 ENOXIMONE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one
Title: Enoximone
CAS Registry Number: 77671-31-9
CAS Name: 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one
Synonyms: 4-methyl-5-[p-(methylthio)benzoyl]-4-imidazolin-2-one; fenoximone
Manufacturers' Codes: MDL-17043; RMI-17043
Trademarks: Perfane (HMR); Perfan (HMR)
Molecular Formula: C12H12N2O2S
Molecular Weight: 248.30
Percent Composition: C 58.05%, H 4.87%, N 11.28%, O 12.89%, S 12.91%
Literature References: Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Prepn: BE 883856 (1980 to Richardson-Merrell); R. A. Schnettler et al., US 4405635 (1983 to Merrell-Dow); eidem, J. Med. Chem. 25, 1477 (1982). Cardiovascular pharmacology in animals: R. C. Dage et al., J. Cardiovasc. Pharmacol. 4, 500 (1982); L. E. Roebel et al., ibid. 721. In vitro mechanism of action studies: T. Kariya et al., ibid. 509; H. S. Ahn et al., Biochem. Pharmacol. 35, 1113 (1986). Acute hemodynamic effects in congestive heart failure: B. F. Uretsky et al., Circulation 67, 823 (1983). HPLC determn in plasma: K. Y. Chan et al., J. Chromatogr. 272, 396 (1983). Pharmacokinetics in humans: R. G. Alken et al., Clin. Pharmacol. Ther. 36, 209 (1984). Symposium on pharmacology and clinical efficacy in congestive heart failure: Am. J. Cardiol. 60, 1C-90C (1987).
Properties: Crystals from isopropanol + water, mp 255-258° (dec).
Melting point: mp 255-258° (dec)
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.