CAS No 77191-36-7 , N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide

Name: N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
Synonyms: DM 9384; Nefiracetamum [INN-Latin]; 77191-36-7; DMPPA;Translon; DM-9384; DZL-221;N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide; N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide;
CAS Registry Number:77191-36-7
Transport: OTH
Melting Point: 151-155 ºC
Density: 1.187 g/cm³
Refractive index: 1.593
Hazard Symbols: UN NO.
Molecular Weight: 246.30492
InchiKey: NGHTXZCKLWZPGK-UHFFFAOYSA-N
InChI: InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/
h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
Risk Statements: 22
Molecular Formula: C₁₄H₁₈N₂O₂
Molecular Structure:

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References of N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide

Title: Nefiracetam
CAS Registry Number: 77191-36-7
CAS Name: N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
Synonyms: 2-(2-oxo-1-pyrrolidinyl)-N-(2,6-dimethylphenyl)acetamide; 2-oxo-1-pyrrolidineaceto-2￠,6￠-xylidide; 2-oxo-1-pyrrolidinylacetic acid 2,6-dimethylanilide; DMMPA
Manufacturers' Codes: DM-9384; DZL-221
Trademarks: Translon (Daiichi)
Molecular Formula: C14H18N2O2
Molecular Weight: 246.30
Percent Composition: C 68.27%, H 7.37%, N 11.37%, O 12.99%
Literature References: Cyclic deriv of g-aminobutyric acid. Prepn: H. Betzing et al., DE 2924011; eidem, US 4341790 (1980, 1982 both to Nattermann). Cognition enhancing effects in rats: T. Sakurai et al., Jpn. J. Pharmacol. 50, 47 (1989). HPLC determn in serum and urine: Y. Fujimaki et al., J. Chromatogr. 575, 261 (1992). Clinical pharmacokinetics: eidem, Xenobiotica 23, 61 (1993). Series of articles on pharmacology and toxicology: Arzneim.-Forsch. 44, 193-259 (1994).
Properties: Crystals from water, mp 153°. LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982).
Melting point: mp 153°
Toxicity data: LD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982)
Therap-Cat: Nootropic.
Keywords: Nootropic.