CAS No 77-15-6 , ethyl 1-methyl-4-phenylazepane-4-carboxylate

Name: ethyl 1-methyl-4-phenylazepane-4-carboxylate
Synonyms: Zactane; Ethoheptazinum [INN-Latin]; ethyl 1-methyl-4-phenylazepane-4-carboxylate;ethyl 1-methyl-4-phenylazepane-4-carboxylate; Ethyl heptazine;Aethoheptazin; Ethoheptazine [BAN];
CAS Registry Number:77-15-6
Density: 1.037 g/cm3
Refractive index: 1.514
EINECS: 201-007-3
Molecular Weight: 261.35932
InchiKey: WGJHHMKQBWSQIY-UHFFFAOYSA-N
InChI: InChI=1S/C16H23NO2/c1-3-19-15(18)16(14-8-5-4-6-9-14)10-7-12-17(2)13-11-
16/h4-6,8-9H,3,7,10-13H2,1-2H3
Molecular Formula: C₁₆H₂₃NO₂
Molecular Structure:

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References of ethyl 1-methyl-4-phenylazepane-4-carboxylate

Title: Ethoheptazine
CAS Registry Number: 77-15-6
CAS Name: Hexahydro-1-methyl-4-phenyl-1H-azepine-4-carboxylic acid ethyl ester
Synonyms: 4-carbethoxy-1-methyl-4-phenylhexamethylenimine; 4-carbethoxy-1-methyl-4-phenylazacycloheptane; ethyl heptazine
Manufacturers' Codes: Wy-401
Molecular Formula: C16H23NO2
Molecular Weight: 261.36
Percent Composition: C 73.53%, H 8.87%, N 5.36%, O 12.24%
Literature References: Prepd in several steps from 2-phenyl-4-dimethylaminobutyronitrile as a starting material, the final step being the hydrolysis and esterification of 1-methyl-4-phenyl-4-cyanoazacycloheptane: Diamond et al., J. Org. Chem. 22, 399 (1957); Diamond, Bruce, US 2666050 (1954 to Am. Home Prod.).
Properties: Liquid. d426 1.038. bp1 133-134°; bp0.5 127-129°; bp0.3 128-130°. nD26 1.5210; nD28 1.5220.
Boiling point: bp1 133-134°; bp0.5 127-129°; bp0.3 128-130°
Index of refraction: nD26 1.5210; nD28 1.5220
Density: d426 1.038

Derivative Type: Hydrochloride
Molecular Formula: C16H23NO2.HCl
Molecular Weight: 297.82
Percent Composition: C 64.53%, H 8.12%, N 4.70%, O 10.74%, Cl 11.90%
Properties: Recrystallized from ethyl acetate + ether, mp 151-153°.
Melting point: mp 151-153°

Derivative Type: Citrate
CAS Registry Number: 6700-56-7
Trademarks: Zactane (Wyeth)
Molecular Formula: C16H23NO2.C6H8O7
Molecular Weight: 453.48
Percent Composition: C 58.27%, H 6.89%, N 3.09%, O 31.75%

Derivative Type: Methobromide
Molecular Formula: C16H23NO2.CH3Br
Molecular Weight: 356.30
Percent Composition: C 57.31%, H 7.36%, N 3.93%, O 8.98%, Br 22.43%
Properties: Crystals from ether, mp 215-217°.
Melting point: mp 215-217°

Therap-Cat: Analgesic.
Keywords: Analgesic (Narcotic).