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CAS No 7689-03-4 , (+)-Camptothecin

  • Name: (+)-Camptothecin
  • Synonyms: (+)-Camptothecine; d-Camptothecin; (S)-Camptothecin; 20(S)-Camptothecine;Camptothecine; 7689-03-4; (S)-(+)-Camptothecin; (+)-Camptothecin;(+)-Camptothecin;
  • CAS Registry Number:
  • Transport: UN 1544
  • Melting Point: 260 ºC
  • Density: 1.51 g/cm3
  • Refractive index: 1.787
  • Safety Statements: R25
  • Hazard Symbols: T: Toxic;
  • EINECS: 444-280-6
  • Molecular Weight: 348.35204
  • InchiKey: VSJKWCGYPAHWDS-FQEVSTJZSA-N
  • InChI: InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-
    22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
  • Risk Statements: S26;S36/37/39;S45
  • Molecular Formula: C20H16N2O4
  • Molecular Structure:CAS No:7689-03-4 (+)-Camptothecin

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References of (+)-Camptothecin
Title: Camptothecin
CAS Registry Number: 7689-03-4
CAS Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3￠,4￠:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Molecular Formula: C20H16N2O4
Molecular Weight: 348.35
Percent Composition: C 68.96%, H 4.63%, N 8.04%, O 18.37%
Literature References: Antitumor alkaloid; prototype DNA topoisomerase I inhibitor. Isoln from the stem wood of the Chinese tree, Camptotheca acuminata Decsne., Nyssaceae, and structure: M. E. Wall et al., J. Am. Chem. Soc. 88, 3888 (1966). Approach to synthesis: Kepler et al., J. Org. Chem. 34, 3853 (1969). Total synthesis: E. J. Corey et al., ibid. 40, 2140 (1975). Total synthesis of racemate: Stork, Schultz, J. Am. Chem. Soc. 93, 4074 (1971); Volkmann et al., ibid. 5576; Tang et al., ibid. 97, 159 (1975); J. C. Bradley, G. Buchi, J. Org. Chem. 41, 699 (1976); T. Kametani et al., J. Chem. Soc. Perkin Trans. 1 1981, 1563. Pharmacologic and clinical evaluation: Gottlieb et al., Cancer Chemother. Rep. Part 1 54, 461 (1970); Gallo et al., J. Natl. Cancer Inst. 46, 789 (1971); S. M. Sieber et al., Cancer Treat. Rep. 60, 1127 (1976). Mechanism of action: Y. H. Hsiang et al., J. Biol. Chem. 260, 14873 (1985). HPLC determn in plasma: J. H. Beijnen et al., J. Chromatogr. 617, 111 (1993). Reviews: M. Potmesil, Cancer Res. 54, 1431-1439 (1994); M. E. Wall, M. C. Wani, ibid. 55, 753-760 (1995).
Properties: Pale yellow needles from methanol + acetonitrile, dec 264-267°. Also reported as mp 275-277° (Volkmann); 287-288° (Stork, Schultz). [a]D25 +31.3° (in chloroform-methanol, 8:2). Exhibits intense blue fluorescence under uv light. uv max: 220, 254, 290, 370 nm (e 37320, 29230, 4980, 19900). Does not form stable salts with acids. Poorly sol in water.
Melting point: mp 275-277° (Volkmann); 287-288° (Stork, Schultz)
Optical Rotation: [a]D25 +31.3° (in chloroform-methanol, 8:2)
Absorption maximum: uv max: 220, 254, 290, 370 nm (e 37320, 29230, 4980, 19900)
 
Derivative Type: Acetate
Molecular Formula: C22H18N2O5
Molecular Weight: 390.39
Percent Composition: C 67.68%, H 4.65%, N 7.18%, O 20.49%
Properties: Crystals, dec 271-274°. uv max: 220, 254, 290, 360-370 nm (e 39010, 28740, 6160, 22000).
Absorption maximum: uv max: 220, 254, 290, 360-370 nm (e 39010, 28740, 6160, 22000)
 
Derivative Type: Chloroacetate
Molecular Formula: C22H17ClN2O5
Molecular Weight: 424.83
Percent Composition: C 62.20%, H 4.03%, Cl 8.35%, N 6.59%, O 18.83%
Properties: Crystals, dec 245-248°.