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CAS No 76168-82-6 , Ramoplanin

  • Name: Ramoplanin
  • Synonyms: Antibiotic A 16686;A 16686;Ramoplanin; A16686A; MDL 62198;
  • CAS Registry Number:
  • Molecular Weight: 0
  • InChI: InChI=1/C106H170ClN21O30/c1-8-9-10-11-15-22-80(140)114-75(50-78(110)138)96(147)118-76(51-79(111)139)97(148)124-86(60-25-36-66(133)37-26-60)102(153)117-72(21-17-46-109)92(143)120-83(56(6)130)100(151)126-89(63-31-42-69(136)43-32-63)105(156)127-88(62-29-40-68(135)41-30-62)104(155)121-82(55(5)129)99(150)119-74(48-58-18-13-12-14-19-58)95(146)116-71(20-16-45-108)93(144)123-87(61-27-38-67(134)39-28-61)103(154)122-84(57(7)131)101(152)125-85(59-23-34-65(132)35-24-59)98(149)112-52-81(141)115-73(47-53(2)3)94(145)113-54(4)91(142)128-90(106(157)158)64-33-44-77(137)70(107)49-64/h10-15,18-19,22,53-57,59-77,82-90,129-137H,8-9,16-17,20-21,23-52,108-109H2,1-7H3,(H2,110,138)(H2,111,139)(H,112,149)(H,113,145)(H,114,140)(H,115,141)(H,116,146)(H,117,153)(H,118,147)(H,119,150)(H,120,143)(H,121,155)(H,122,154)(H,123,144)(H,124,148)(H,125,152)(H,126,151)(H,127,156)(H,128,142)(H,157,158)/b11-10-,22-15-/t54-,55+,56+,57+,59?,60?,61?,62?,63?,64?,65?,66?,67?,68?,69?,70?,71-,72-,73+,74+,75+,76?,77?,82+,83-,84+,85?,86-,87?,88-,89-,90?/m1/s1
  • Molecular Formula: C106H170ClN21O30
  • Molecular Structure:CAS No:76168-82-6 Ramoplanin
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76168-82-6 Ramoplanin

  • Ramoplanin is used as a treatment for multiple antibiotic-resistant Clostridium difficile infection of the gastrointestinal tract. More information please visit the website: https://www.creative-peptides.com/product/ramoplanin-item-10-101-105-92.html
  • Min. Order: 10
  • United States Creative Peptides [Manufacturer]
  • Tel: 1-631-6244882
  • Fax: 1-631-6147828
  • Address: Ramsey Road Shirley,New YorkUnited States
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76168-82-6 Ramoplanin

  • China Xingcheng Chempharm Co., Ltd [Manufacturer]
  • Tel: +86-576-88525005/ +86-576-88886292
  • Fax: +86-576-88225056
  • Address: B Area, 10F, Yaoda Mansion, 289, Shifu Road, Taizhou, Zhejiang, China 318000 null,nullChina
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76168-82-6 Ramoplanin

  • United States Tecoland Corporation null
  • Tel: +1-(732)-603-9577
  • Fax: +1-(732)-906-1522
  • Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428, null,nullUnited States
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References of Ramoplanin
Title: Ramoplanin
CAS Registry Number: 76168-82-6
Synonyms: A-16686
Manufacturers' Codes: MDL-62198
Literature References: Glycolipodepsipeptide antibiotic complex consisting of 6 related components (A1, A2, A3, A￠1, A￠2, A￠3) of which A2 is the most abundant. Isoln and inital characterization from Actinoplanes sp.: B. Cavalleri et al., DE 3013246; eidem, US 4303646 (1980, 1981 both to Gruppo Lepetit); idem et al., J. Antibiot. 37, 309 (1984). Bactericidal activity: R. Pallanza et al., ibid. 318. Structure elucidation: R. Ciabatti et al., ibid. 42, 254 (1989); and sequence determn: J. K. Kettenring et al., ibid. 268. 3D structure: M. Kurz, W. Guba, Biochemistry 35, 12570 (1996). Isoln and characterization of the A￠ factors: L. Gastaldo et al., J. Indus. Microbiol. 11, 13 (1992). Determn in sera: M. T. Kenny et al., Diagn. Microbiol. Infect. Dis. 18, 117 (1994). Clinical evaluation against vancomycin resistant enterococci (VRE): M. T. Wong et al., Clin. Infect. Dis. 33, 1476 (2001). Review of discovery and chemistry: F. Parenti et al., Drugs Exp. Clin. Res. 16, 451-455 (1990); of chemistry and mechanism of action: S. Walker et al., Chem. Rev. 105, 449-475 (2005); of pharmacology and clinical potential: D. K. Farver et al., Ann. Pharmacother. 39, 863-868 (2005).
Properties: White powder, slightly hygroscopic. mp 210-230°. [a]D20 +78.3° (c = 1.04 in H2O). Sol in DMF and lower alcohols. Insol in ethyl ether, petroleum ether and benzene. LD50 in mice (mg/kg): 328 i.p., 122 i.v.; orally in rats: 2000 mg/kg (Pallanza).
Melting point: mp 210-230°
Optical Rotation: [a]D20 +78.3° (c = 1.04 in H2O)
Toxicity data: LD50 in mice (mg/kg): 328 i.p., 122 i.v.; orally in rats: 2000 mg/kg (Pallanza)
 
Derivative Type: Ramoplanin A2
CAS Registry Number: 81988-88-7
Molecular Formula: C119H154ClN21O40
Molecular Weight: 2554.07
Percent Composition: C 55.96%, H 6.08%, Cl 1.39%, N 11.52%, O 25.06%
Literature References: Total synthesis: W. Jiang et al., J. Am. Chem. Soc. 124, 5288 (2002); eidem, ibid. 125, 1877 (2003).
Properties: White powder, mp 210-220°. [a]D20 +73±4° (c = 0.49 in H2O). uv max in methanol: 234, 268 nm (E1cm1% 206, 114).
Melting point: mp 210-220°
Optical Rotation: [a]D20 +73±4° (c = 0.49 in H2O)
Absorption maximum: uv max in methanol: 234, 268 nm (E1cm1% 206, 114).
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Polypeptides.