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CAS No 75-21-8 , oxirane

  • Name: oxirane
  • Synonyms: ETHYLENE OXIDE; Oxacyclopropane; Anprolene;oxirane; Dimethylene oxide; Anproline; Amprolene;Oxirane; Dihydrooxirene; Epoxyethane;
  • CAS Registry Number:
  • Transport: UN 2037
  • Density: 0.994 g/cm3
  • Refractive index: n20/D 1.3597(lit.)
  • Safety Statements: Confirmed human carcinogen with experimental carcinogenic, tumorigenic, neoplastigenic, and teratogenic data. Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by inhalation. Human systemic effects by inhalation: convulsions, nausea, vomiting, olfactory and pulmonary changes. Experimental reproductive effects. Mutation data reported. A skin and eye irritant. An irritant to mucous membranes of respiratory tract. High concentrations can cause pulmonary edema.

    Highly flammable liquid or gas. Severe explosion hazard when exposed to flame. To fight fire, use alcohol foam, CO2, dry chemical. Violent polymerization occurs on contact with ammonia, alkali hydroxides, amines, metallic potassium, acids, covalent halides (e.g., aluminum chloride, iron(III) chloride, tin(IV) chloride, aluminum oxide, iron oxide, rust). Explosive reaction with glycerol at 200°. Rapid compression of the vapor with air causes explosions. Incompatible with bases, alcohols, air, m-nitroaniline, trimethyl amine, copper, iron chlorides, iron oxides, magnesium perchlorate, mercaptans, potassium, tin chlorides, contaminants, alkane thiols, bromoethane. When heated to decomposition it emits acrid smoke and irritating fumes.

    Analytical Methods:

       

    For occupational chemical analysis use OSHA: #30, SUPERSEDED BY #50 or NIOSH: Ethylene Oxide, 1614; (Portable GC), 3702.

  • Hazard Symbols: Irritant to eyes and skin. TLV: 1 ppm; suspected human carcinogen. Highly flammable, dangerous fire and explosion risk, flammable limits in air 3–100%.
  • EINECS: 200-849-9
  • Molecular Weight: 44.05256
  • InchiKey: IAYPIBMASNFSPL-UHFFFAOYSA-N
  • InChI: InChI=1S/C2H4O/c1-2-3-1/h1-2H2
  • Risk Statements: 45-46-12-23-36/37/38
  • Molecular Formula: C2H4O
  • Molecular Structure:CAS No:75-21-8 oxirane
References of oxirane
Title: Ethylene Oxide
CAS Registry Number: 75-21-8
CAS Name: Oxirane
Trademarks: Anprolene
Molecular Formula: C2H4O
Molecular Weight: 44.05
Percent Composition: C 54.53%, H 9.15%, O 36.32%
Literature References: Prepd from ethylene chlorohydrin and KOH: A. Wurtz, Ann. 110, 125 (1859). Manuf by catalytic oxidation of ethylene: T. E. Lefort, US 1998878 (1935 to Société Fran?aise de Catalyse Généralisée) reissued as US RE 20370 (1937 to Carbide and Carbon). Physical props: W. H. Perkin, J. Chem. Soc. 63, 488 (1893). Leukemia in workers exposed to ethylene oxide: C. Hogstedt et al., J. Am. Med. Assoc. 241, 1132 (1979). Hazards and handling: L. G. Hess, V. V. Tilton, Ind. Eng. Chem. 42, 1251 (1950). Genotoxicity: E. Agurell et al., Mutat. Res. 250, 229 (1991). Review of toxicology and human exposure: Toxicological Profile for Ethylene Oxide (PB91-180554, 1990) 115 pp; of carcinogenic risk: IARC Monographs 60, 73-159 (1994). Review: H. C. Schultze in Glycols, G. O. Curme, Jr., Ed. (Reinhold, New York, 1952) pp 74-113; J. P. Dever et al., in Kirk-Othmer Encyclopedia of Chemical Technology vol. 9 (John Wiley & Sons, New York, 4th ed., 1994) pp 915-959.
Properties: Colorless, flammable gas at ordinary room temp and pressure; liquid below 12°. Explosive! bp 10.7°. d44 0.891, d77 0.887, d1010 0.882. mp -111°. nD7 1.3597. Sol in water, alcohol, ether.
Melting point: mp -111°
Boiling point: bp 10.7°
Index of refraction: nD7 1.3597
Density: d44 0.891; d77 0.887; d1010 0.882
CAUTION: Potential symptoms of overexposure are irritation of eyes, skin, nose and throat; peculiar taste; headache; nausea, vomiting and diarrhea; dyspnea, cyanosis and pulmonary edema; drowsiness, incoordination; EKG abnormalities; reproductive effects; direct contact with liquid or high vapor concentrations may cause burns to eyes and skin; direct contact with liquid may cause frostbite. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 138. This substance is listed as a known human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-118.
Use: Fumigant for foodstuffs and textiles; to sterilize surgical instruments; agricultural fungicide. In organic syntheses, esp in the production of ethylene glycol. Starting material for the manuf of acrylonitrile and nonionic surfactants.