Title: Piracetam
CAS Registry Number: 7491-74-9
CAS Name: 2-Oxo-1-pyrrolidineacetamide
Synonyms: 2-pyrrolidoneacetamide; 2-pyrrolidinoneacetamide; 2-ketopyrrolidine-1-ylacetamide; 1-acetamido-2-pyrrolidinone
Manufacturers' Codes: UCB-6215
Trademarks: Avigilen (Riemser); Axonyl (Pfizer); Cerebroforte (Azupharma); Encetrop (Alpharma); Gabacet (Sanofi-Synthelabo); Geram (UCB); Nootrop (UCB); Nootropil (UCB); Nootropyl (UCB); Norzetam (UCB); Normabra?n (UCB); Piracebral (Hexal); Piracetrop (Holsten); Sinapsan (Rodleben)
Molecular Formula: C6H10N2O2
Molecular Weight: 142.16
Percent Composition: C 50.69%, H 7.09%, N 19.71%, O 22.51%
Literature References: Prepn: H. Morren,
NL 6509994;
eidem, US 3459738 (1966, 1969 both to U.C.B.). Pharmacology: Giurgea
et al., Arch. Int. Pharmacodyn. Ther. 166, 238 (1967); Giurgea, Moyersoons,
ibid. 188, 401 (1970); Giurgea
et al., Psychopharmacologia 20, 160 (1971). Metabolism and biochemical studies: Gobert,
J. Pharm. Belg. 27, 281 (1972). Clinical studies: W. J. Oosterveld,
Arzneim.-Forsch. 30, 1947 (1980); G. Chouinard
et al., Psychopharmacol. Bull. 17, 129 (1981); in dyslexia: M. Di Ianni
et al., J. Clin. Psychopharmacol. 5, 272 (1985).
Properties: Crystals from isopropanol, mp 151.5-152.5°.
Melting point: mp 151.5-152.5°
Therap-Cat: Nootropic.
Keywords: Nootropic.
