CAS No 73573-42-9 , Yohimban-16-carboxylicacid,18-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propenyl]oxy]-11,17-dimethoxy-,methyl ester, (3b,16b,17a,18b,20a)- (9CI)

Name: Yohimban-16-carboxylicacid,18-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propenyl]oxy]-11,17-dimethoxy-,methyl ester, (3b,16b,17a,18b,20a)- (9CI)
Synonyms: Toscarna; WHO 4939;Rescimetol;Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv.;Yohimban-16-carboxylicacid,18-[[3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propenyl]oxy]-11,17-dimethoxy-,methyl ester, [3b,16b,17a,18b(E),20a]-;Yohimban-16-carboxylicacid,18-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propenyl]oxy]-11,17-dimethoxy-,methyl ester, (3b,16b,17a,18b,20a)- (9CI);
CAS Registry Number:73573-42-9
Flash Point: 400.6°C
Boiling Point: 738.7°C at 760 mmHg
Density: 1.35g/cm³
Refractive index: 1.646
Flash Point: 400.6°C
Molecular Weight: 0
InChI: InChI=1/C33H38N2O8/c1-39-20-7-8-21-22-11-12-35-17-19-14-28(43-29(37)10-6-18-5-9-26(36)27(13-18)40-2)32(41-3)30(33(38)42-4)23(19)16-25(35)31(22)34-24(21)15-20/h5-10,13,15,19,23,25,28,30,32,34,36H,11-12,14,16-17H2,1-4H3/b10-6+/t19-,23?,25-,28-,30+,32+/m1/s1
Molecular Formula: C33H38N2O8
Molecular Structure:

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References of Yohimban-16-carboxylicacid,18-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propenyl]oxy]-11,17-dimethoxy-,methyl ester, (3b,16b,17a,18b,20a)- (9CI)

Title: Rescimetol
CAS Registry Number: 73573-42-9
CAS Name: [3b,16b,17a,18b,20a]-18-[[(2E)-3-(4-Hydroxy-3-methoxyphenyl)-1-oxo-2-propenyl]oxy]-11,17-dimethoxyyohimban-16-carboxylic acid methyl ester
Synonyms: methyl O-(4-hydroxy-3-methoxycinnamoyl)reserpate
Manufacturers' Codes: CD-3400; WHO-4939
Trademarks: Toscarna (Nippon Chemiphar)
Molecular Formula: C33H38N2O8
Molecular Weight: 590.66
Percent Composition: C 67.10%, H 6.48%, N 4.74%, O 21.67%
Literature References: Analog of rescinnamine. Prepn: BE 782661 corresp to T. Kametani, US 3898215 (1972, 1975 both to Nippon Chemiphar); T. Kametani et al., J. Med. Chem. 15, 686 (1972). Mass spectrum: eidem, J. Chem. Soc. Perkin Trans. 1 1975, 932. Antihypertensive activity: H. Kato et al., Jpn. J. Pharmacol. 27, 87 (1977). Effects on respiration, cardiovascular system, renal function: T. Kamishiro et al., Oyo Yakuri 20, 441 (1980), C.A. 96, 28430w (1982). Toxicity study: T. Fukuda et al., ibid. 18, 71 (1979), C.A. 92, 104392v (1980).
Properties: Pale yellow needles from methanol, mp 259-260°.
Melting point: mp 259-260°
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive.

Status: This monograph has been retired and is no longer subject to revision or update.