Home > Name List By m > methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E, 3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate China

CAS No 73121-56-9 , methyl
7-[(1R,2R,3R)-3-hydroxy-2-[(E,
3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate Search by region : China

  • Name: methyl
    7-[(1R,2R,3R)-3-hydroxy-2-[(E,
    3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate
  • Synonyms: Camleed (TN); 73121-56-9; AC1NSK92; Syngard;RS-84135;methyl
    7-[(1R,2R,3R)-3-hydroxy-2-[(E,
    3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate; Gardrine; CHEMBL2104194; Camleed; Enprostil (JAN/USAN/INN);
  • CAS Registry Number:
  • Flash Point: 185.7°C
  • Boiling Point: 552.9°C at 760 mmHg
  • Density: 1.201g/cm3
  • Refractive index: 1.586
  • Safety Statements: A poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
  • Hazard Symbols: Moderately toxic by ingestion.
  • Flash Point: 185.7°C
  • Molecular Weight: 400.46482
  • InchiKey: PTOJVMZPWPAXER-VFJVYMGBSA-N
  • InChI: InChI=1S/C23H28O6/c1-28-23(27)12-8-3-2-7-11-19-20(22(26)15-21(19)25)14-
    13-17(24)16-29-18-9-5-4-6-10-18/h3-7,9-10,13-14,17,19-20,22,24,26H,8,
    11-12,15-16H2,1H3/b14-13+/t2?,17-,19-,20-,22-/m1/s1
  • Molecular Formula: C23H28O6
  • Molecular Structure:CAS No:73121-56-9 methyl<br />7-[(1R,2R,3R)-3-hydroxy-2-[(E,<br />3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate

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References of methyl
7-[(1R,2R,3R)-3-hydroxy-2-[(E,
3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate
Title: Enprostil
CAS Registry Number: 73121-56-9
CAS Name: rel-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-butenyl]-5-oxocyclopentyl]-4,5-heptadienoic acid methyl ester
Synonyms: (dl)-9-keto-11a,15a-dihydroxy-16-phenoxy-17,18,19,20-tetranorprosta-4,5,13-trans-trienoic acid methyl ester
Manufacturers' Codes: RS-84135
Trademarks: Camleed (Tanabe Seiyaku); Gardrin(e) (Syntex)
Molecular Formula: C23H28O6
Molecular Weight: 400.46
Percent Composition: C 68.98%, H 7.05%, O 23.97%
Literature References: Prostaglandin E2 derivative with antisecretory activity. Prepn: A. R. Van Horn et al., US 4178457 (1979 to Syntex). Pharmacokinetics: D. R. Stanski et al., Clin. Pharmacol. Ther. 31, 273 (1982). Cytoprotective effect against aspirin-induced gastromucosal injury in humans: M. M. Cohen et al., Gastroenterology 88, 382 (1985). Clinical comparison with cimetidine of antisecretory and antigastrin activity in duodenal ulcer: V. Mahachai et al., ibid. 89, 555 (1985); of efficacy in ulcer healing: L. Carling et al., Scand. J. Gastroenterol. 22, 325 (1987). Series of articles on pharmacology, clinical efficacy and safety: Am. J. Med. 81, Suppl. 2A, 1-88 (1986).
Properties: White to off-white waxy solid. Softens at 30°, liquid at 46°. Very slightly sol in water. Sol in alcohol, propylene glycol, propylene carbonate. uv max (methanol): 220, 265, 271, 277 nm (log e 4.01, 3.14, 3.24, 3.16).
Absorption maximum: uv max (methanol): 220, 265, 271, 277 nm (log e 4.01, 3.14, 3.24, 3.16)
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Prostaglandin/Prostaglandin Analog.