Home > Name List By a > Acetic acid,2-[3-methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene]-, ethyl ester

CAS No 73-09-6 , Acetic acid,2-[3-methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene]-, ethyl ester

  • Name: Acetic acid,2-[3-methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene]-, ethyl ester
  • CAS Registry Number:
  • Flash Point: 225.6°C
  • Boiling Point: 449.4°C at 760 mmHg
  • Density: 1.288g/cm3
  • Refractive index: 1.614
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Used as a diuretic. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also ESTERS.
  • Flash Point: 225.6°C
  • EINECS: 200-794-0
  • Molecular Weight: 284.41
  • InChI: InChI=1/C13H20N2O3S/c1-3-18-11(16)9-10-14(2)12(17)13(19-10)15-7-5-4-6-8-15/h9,13H,3-8H2,1-2H3/b10-9+
  • Molecular Formula: C13H20 N2 O3 S
  • Molecular Structure:CAS No:73-09-6 Acetic acid,2-[3-methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene]-, ethyl ester

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References of Acetic acid,2-[3-methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene]-, ethyl ester
Title: Etozolin
CAS Registry Number: 73-09-6
CAS Name: [3-Methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene]acetic acid ethyl ester
Synonyms: 2-carbethoxymethylene-3-methyl-5-piperidino-4-thiazolidone; 3-methyl-4-oxo-5-piperidino-D2,a-thiazolidineacetic acid ethyl ester
Manufacturers' Codes: G?-687; W-2900A
Trademarks: Elkapin (Gecke)
Molecular Formula: C13H20N2O3S
Molecular Weight: 284.37
Percent Composition: C 54.91%, H 7.09%, N 9.85%, O 16.88%, S 11.28%
Literature References: A member of a new class of heterocyclic compounds, the 2-methylenethiazolidones; a diuretic with choleretic properties. Prepn: Satzinger, Ann. 665, 150 (1963); US 3072653 (1963 to Warner-Lambert). Pharmacology: O. Heidenreich et al., Arzneim.-Forsch. 14, 1242 (1964). Series of articles on activity, metabolism and toxicology: G. Satzinger et al., ibid. 27, 1742-1817 (1977); M. Herrmann et al., ibid. 1745.
Properties: Crystals from methanol, mp 140°. uv max (methanol): 283, 243 nm (log e 4.32, 4.0). LD50 in male mice, rats (mg/kg): 1210, 1575 i.p.; in male, female mice, rats (mg/kg): 8670, 9360, 11040, 10250 orally (Herrmann).
Melting point: mp 140°
Absorption maximum: uv max (methanol): 283, 243 nm (log e 4.32, 4.0)
Toxicity data: LD50 in male mice, rats (mg/kg): 1210, 1575 i.p.; in male, female mice, rats (mg/kg): 8670, 9360, 11040, 10250 orally (Herrmann)
 
Derivative Type: Hydrochloride
Molecular Formula: C13H20N2O3S.HCl
Molecular Weight: 320.84
Percent Composition: C 48.67%, H 6.60%, N 8.73%, O 14.96%, S 9.99%, Cl 11.05%
Properties: Crystals, mp 158-159°.
Melting point: mp 158-159°
 
Derivative Type: Free acid
Synonyms: Ozolinone
Manufacturers' Codes: G?decke 3282
Molecular Formula: C11H16N2O3S
Molecular Weight: 256.32
Percent Composition: C 51.54%, H 6.29%, N 10.93%, O 18.73%, S 12.51%
 
Therap-Cat: Diuretic.
Keywords: Diuretic.