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CAS No 71125-38-7 , 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ

  • Name: 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ
  • Synonyms: Metacam; Movatec; Parocin; Mobicox; Mobec; Meloxicamum [Latin]; Tenaron; Movalis;6,
    2-benzothiazine-3-carboxamide;4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λMobic;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 3
  • Melting Point: 255 °C
  • Density: 1.613 g/cm3
  • Refractive index: 1.72
  • Water Solubility: DMSO: soluble
  • Safety Statements: 26
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 351.40072
  • InchiKey: ZRVUJXDFFKFLMG-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10
    (9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
  • Risk Statements: 22-36/37/38
  • Molecular Formula: C14H13N3O4S2
  • Molecular Structure:CAS No:71125-38-7 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ

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References of 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ
Title: Meloxicam
CAS Registry Number: 71125-38-7
CAS Name: 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
Trademarks: Metacam (Boehringer, Ing.); Mobec (Boehringer, Ing.); Mobic (Boehringer, Ing.); Mobicox (Boehringer, Ing.); Movalis (Boehringer, Ing.); Movatec (Boehringer, Ing.); Parocin (Almirall)
Molecular Formula: C14H13N3O4S2
Molecular Weight: 351.40
Percent Composition: C 47.85%, H 3.73%, N 11.96%, O 18.21%, S 18.25%
Literature References: Preferential cyclooxygenase (COX-2) inhibitor. Prepn: G. Trummlitz et al., DE 2756113 (1979 to Thomae); eidem, US 4233299 (1980 to Boehringer Ingelheim). Pharmacology in horses: P. Lees et al., Br. Vet. J. 147, 97 (1991). Physicochemical properties: R.-S. Tsai et al., Helv. Chim. Acta 76, 842 (1993). Veterinary trial in dogs: A. J. Henderson et al., Prakt. Tierarzt 75, 179 (1994). Series of articles on pharmacology, mechanism of action and clinical efficacy: Br. J. Rheumatol. 35, Suppl. 1, 1-77 (1996). Clinical trials of GI tolerability in arthritis: C. Hawkey et al., ibid. 37, 937 (1998); J. Dequeker et al., ibid. 946. Review of clinical experience: R. Fleischmann et al., Expert Opin. Pharmacother. 3, 1501-1512 (2002).
Properties: Crystals from ethylene chloride, mp 254° (dec). pKa: 4.08 in water; 4.24 ± 0.01 in water/ethanol (1:1); 4.63 ± 0.03 in water/ethanol (1:4). Log P (octanol/water): 3.02. LD50 orally in mice: 470 mg/kg (Trummlitz, 1980).
Melting point: mp 254° (dec)
pKa: pKa: 4.08 in water; 4.24 ± 0.01 in water/ethanol (1:1); 4.63 ± 0.03 in water/ethanol (1:4)
Log P: Log P (octanol/water): 3.02
Toxicity data: LD50 orally in mice: 470 mg/kg (Trummlitz, 1980)
Therap-Cat: Anti-inflammatory.
Therap-Cat-Vet: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Thiazinecarboxamides.