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CAS No 71-00-1 , L-Histidine Search by region : Switzerland

  • Name: L-Histidine
  • Synonyms: L-Histidine Base; H-His-OH;His; L-2-Amino-3-(4-imidazolyl)propionic acid;L-Histidine,free base; His;L-Histidine; L-HIS = H-His-OH; (S)-2-Amino-3-(4-imidazolyl)propionic acid~H-His-OH;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 282 ºC
  • Flash Point: 282ºC
  • Boiling Point: 458.9ºC at 760 mmHg
  • Density: 1.423 g/cm3
  • Refractive index: 13 ° (C=11, 6mol/L HCl)
  • Alpha: 12.4 º (C=11,6N HCL)
  • Water Solubility: 41.6 G/L (25 ºC)
  • Safety Statements: 24/25-36/37-26-22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 282ºC
  • EINECS: 200-745-3
  • Molecular Weight: 155.16
  • InChI: InChI=1/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
  • Risk Statements: S24/25
  • Molecular Formula: C6H9N3O2
  • Molecular Structure:CAS No:71-00-1 L-Histidine

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71-00-1 L-Histidine

  • L-HistidineH-His-OH
  • Switzerland Biosynth AG [Manufacturer]
  • Tel: +41 71 858 20 20/ 630.305.8400 (USA)
  • Fax: +41 71 858 20 30
  • Address: BIOSYNTH AG
    Rietlistrasse 4
    9422 Staad / Switzerland
    Phone: +41 (0)71 858 20 20
    Fax: +41 (0)71 858 20 30 null,nullSwitzerland
Contact Supplier

71-00-1 H-His-OH

  • H-His-OHL-Histidine
  • Switzerland Senn Chemicals AG [Manufacturer]
  • Tel: +41 (0)43 422 2400
  • Fax: +41 (0)43 422 2424
  • Address: Senn Chemicals AG
    P.O. Box 267
    Guido Senn Strasse 1, CH-8157 Dielsdorf
    Switzerland null,nullSwitzerland
Contact Supplier

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References of L-Histidine
Title: Histidine
CAS Registry Number: 71-00-1
CAS Name: L-Histidine
Synonyms: His; H; (S)-a-amino-1H-imidazole-4-propanoic acid; a-amino-4(or 5)-imidazolepropionic acid; glyoxaline-5-alanine
Molecular Formula: C6H9N3O2
Molecular Weight: 155.15
Percent Composition: C 46.45%, H 5.85%, N 27.08%, O 20.62%
Literature References: Essential amino acid for human development; precursor to histamine and a component of carnosine, q.v. Independently isolated in 1896 by both A. Kossel and S. G. Hedin, Zeit. Physiol. 22, 176, 191 (1896). Early chemistry and biochemistry: Amino Acids and Proteins, D. M. Greenberg, Ed. (Charles C. Thomas, Springfield, IL, 1951) 950 pp., passim; J. P. Greenstein, M. Winitz, Chemistry of the Amino Acids vols 1-3 (John Wiley and Sons, Inc., New York, 1961) pp. 1971-1995, passim. NMR spectra: D. H. Sachs et al., J. Biol. Chem. 246, 6576 (1971). HPLC determn in dipeptides: E. Kasziba et al., J. Chromatogr. 432, 315 (1988). Often found at the active site of proteins: W. T. Morgan et al., J. Biol. Chem. 268, 6256 (1993); J.-W. P. Boots et al., Biochim. Biophys. Acta 1248, 27 (1995). Role in proton translocation - a model: J. E. Morgan et al., J. Bioenerg. Biomembr. 26, 599 (1994). Review of metabolism: F. B. Stifel, R. H. Herman, Am. J. Clin. Nutr. 24, 207-217 (1971). Review of role in nutrition: eidem, ibid. 25, 182-185 (1972); L. P. Mercer et al., Nutrition 6, 273-277 (1990).
Properties: Sweet needles or plates, dec 287° (softens at 277°). [a]D20 -10.9° (c = 0.77 in 0.5N NaOH); [a]D25 -38.95° (c = 0.75 to 3.77); [a]D25 +13.34° (c = 1.00-4.05 in 6.1N HCl). pK1 1.82; pK2 6.00; pK3 9.17. Soly in water at 25°: 41.9 g/l. Insol in common neutral solvents except water.
pKa: pK1 1.82; pK2 6.00; pK3 9.17
Optical Rotation: [a]D20 -10.9° (c = 0.77 in 0.5N NaOH); [a]D25 -38.95° (c = 0.75 to 3.77); [a]D25 +13.34° (c = 1.00-4.05 in 6.1N HCl)
 
Derivative Type: Monohydrochloride
Trademarks: Ecristidine; Laristine (Roche); Larostidin (Roche); Plexamine (Biodica)
Molecular Formula: C6H9N3O2.HCl
Molecular Weight: 191.62
Percent Composition: C 37.61%, H 5.26%, N 21.93%, O 16.70%, Cl 18.50%
Properties: Rhombic crystals, dec 251-252° (also forms a monohydrate, mp 80°, anhydrous, mp at 140°). [a]D26 +8.0° (c = 2 in 3 mols HCl). Fairly sol in water. Insol in alcohol, ether.
Melting point: Rhombic crystals, dec 251-252° (also forms a monohydrate, mp 80°, anhydrous, mp at 140°)
Optical Rotation: [a]D26 +8.0° (c = 2 in 3 mols HCl)
 
Derivative Type: DL-Form
Properties: Quadrilateral plates or tetragonal prisms, dec 285°. Sol in water.