Title: Troxerutin
CAS Registry Number: 7085-55-4
CAS Name: 2-[3,4-Bis(2-hydroxyethoxy)phenyl]-3-[[6-
O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-4
H-1-benzopyran-4-one
Synonyms: 7,3￠,4￠-tris[
O-(2-hydroxyethyl)]rutin; trioxyethylrutin; tri(hydroxyethyl)rutoside
Trademarks: Posorutin (Ursapharm); Ruven (Mepha); Vastribil (Farmasan); Veinamitol (NEGMA); Veniten (Wyeth)
Molecular Formula: C33H42O19
Molecular Weight: 742.68
Percent Composition: C 53.37%, H 5.70%, O 40.93%
Literature References: The principal component of a mixture, the
O-(b-hydroxyethyl)rutosides, which also contains mono-, di-, tetra- and other trihydroxyethyl derivs of rutin,
q.v. The mixture is prepd by the hydroxyethylation of the phenolic groups of rutin with glycochlorohydrin in alk medium: J. Favre,
CH 349614 (1957);
see also GB 833174 (1960 to Zyma),
C.A. 54, 21135i (1960). Isolation and identification of major components of the mixture: P. Courbat
et al., Helv. Chim. Acta 49, 1203, 1420 (1966). Prepn of troxerutin: P. J. Courbat,
US 3420815 (1969 to Zyma). Metabolism in man: A. M. Hackett
et al., Arzneim.-Forsch. 26, 925 (1976).
Properties: Yellow powder, mp 181°. Sol in water, glycerol, propylene glycol. Practically insol in cold ethanol, methanol (forms alcoholate), ether, benzene, chloroform.
Melting point: mp 181°
Derivative Type: O-(b-Hydroxyethyl)rutinosides (mixture)
CAS Registry Number: 55965-63-4
Synonyms: HR
Trademarks: Paroven (Zyma); Relvene (Pharmascience); Varemoid (Zyma); Venoruton (Zyma)
Properties: Yellow powder, mp 156°. Sol in water, methanol, glycerol, propylene glycol. Practically insol in cold ethanol (forms alcoholate), ether, benzene, chloroform.
Melting point: mp 156°
Therap-Cat: Treatment of venous disorders.
Keywords: Vasoprotectant.
