CAS No 7008-26-6 , Pregna-1,4-diene-3,20-dione,9,11-dichloro-17,21-dihydroxy-, (11b)-

Name: Pregna-1,4-diene-3,20-dione,9,11-dichloro-17,21-dihydroxy-, (11b)-
Synonyms: 9a,11b-Dichloro-17a,21-dihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione,9,11b-dichloro-17,21-dihydroxy-(6CI,7CI,8CI);Pregna-1,4-diene-3,20-dione,9,11-dichloro-17,21-dihydroxy-, (11b)-;Dichlorisone;
CAS Registry Number:7008-26-6
Flash Point: 308.4°C
Boiling Point: 586.4°C at 760 mmHg
Density: 1.37g/cm³
Refractive index: 1.607
Flash Point: 308.4°C
EINECS: 230-283-8
Molecular Weight: 413.3347
InChI: InChI=1/C21H26Cl2O4/c1-18-7-5-13(25)9-12(18)3-4-15-14-6-8-20(27,17(26)11-24)19(14,2)10-16(22)21(15,18)23/h5,7,9,14-16,24,27H,3-4,6,8,10-11H2,1-2H3/t14?,15?,16?,18?,19?,20-,21-/m0/s1
Molecular Formula: C21H26 Cl2 O4
Molecular Structure:

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7008-26-6 Pregna-1,4-diene-3,20-dione,9,11-dichloro-17,21-dihydroxy-, (11b)-

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7008-26-6 DICHLORISONE

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References of Pregna-1,4-diene-3,20-dione,9,11-dichloro-17,21-dihydroxy-, (11b)-

Title: Dichlorisone
CAS Registry Number: 7008-26-6
CAS Name: (11b)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione
Synonyms: 9a,11b-dichloro-1,4-pregnadiene-17a,21-diol-3,20-dione; 9a,11b-dichloro analog of prednisolone
Trademarks: Diloderm (Schering); Disoderm (Schering)
Molecular Formula: C21H26Cl2O4
Molecular Weight: 413.33
Percent Composition: C 61.02%, H 6.34%, Cl 17.15%, O 15.48%
Literature References: Prepn: Robinson et al., J. Am. Chem. Soc. 81, 2191 (1959); Gould et al., US 2894963 (1959 to Schering).
Properties: Crystals from acetone, dec 238-241°. [a]D20 +134° (pyridine). uv max (methanol): 237 nm (e 15400).
Optical Rotation: [a]D20 +134° (pyridine)
Absorption maximum: uv max (methanol): 237 nm (e 15400)

Derivative Type: 21-Acetate
CAS Registry Number: 79-61-8
Trademarks: Astroderm (Medix)
Molecular Formula: C23H28Cl2O5
Molecular Weight: 455.37
Percent Composition: C 60.66%, H 6.20%, Cl 15.57%, O 17.57%
Properties: Crystals from acetone, dec 246-253°. [a]D25 +162° (dioxane). uv max (methanol): 237 nm (e 15000).
Optical Rotation: [a]D25 +162° (dioxane)
Absorption maximum: uv max (methanol): 237 nm (e 15000)

Therap-Cat: Antipruritic (topical).
Keywords: Antipruritic.