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CAS No 6998-60-3 , rifamycin

  • Name: rifamycin
  • Synonyms: Rifamicina; Rifomycin SV; Rifamycine; Rifocin; Rifamycin SV; Rifamycinum;RIFAMYCIN;rifamycin; Rifocyn; Rifamicine SV;
  • CAS Registry Number:
  • Safety Statements: Poison by intracerebral route. Moderately toxic by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Used as an antibacterial agent.
  • EINECS: 230-273-3
  • Molecular Weight: 697.76858
  • InchiKey: HJYYPODYNSCCOU-ODRIEIDWSA-N
  • InChI: InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32
    (23)44)31(43)21(6)34-28(26)35(45)37(8,
    50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-
    16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,
    18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
  • Molecular Formula: C37H47NO12
  • Molecular Structure:CAS No:6998-60-3 rifamycin

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6998-60-3 RIFAMYCIN SV

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6998-60-3 RIFAMYCIN

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References of rifamycin
Title: Rifamycin SV
CAS Registry Number: 6998-60-3
CAS Name: 5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate
Synonyms: rifomycin SV; rifamicine SV
Molecular Formula: C37H47NO12
Molecular Weight: 697.77
Percent Composition: C 63.69%, H 6.79%, N 2.01%, O 27.52%
Literature References: Semi-synthetic antibiotic derived from Rifamycin S. Prepn: Sensi et al., Experientia 16, 412 (1960); Farmaco Ed. Sci. 16, 165 (1961). Comprehensive review: Bergamini, Fowst, Arzneim.-Forsch. 15, 951-1002 (1965). For general refs see Rifamycins.
Properties: Yellow-orange crystals, mp 300° (dec 140°). [a]D20 -4° (methanol). uv max (phosphate buffer soln pH 7.3): 223, 314, 445 nm (E1%1cm 586, 322, 204). Acid reaction. Slightly sol in water, petr ether; sol in ether, bicarbonate soln; very sol in methanol, ethanol, acetone, ethyl acetate. A reducing substitute, such as ascorbic acid, should be added to aq solns of rifamycin SV to prevent its transformation to rifamycin S. LD50 in mice (mg/kg): 550 i.v.; 625 i.p.; 2120 orally (Bergamini, Fowst).
Melting point: mp 300° (dec 140°)
Optical Rotation: [a]D20 -4° (methanol)
Absorption maximum: uv max (phosphate buffer soln pH 7.3): 223, 314, 445 nm (E1%1cm 586, 322, 204)
Toxicity data: LD50 in mice (mg/kg): 550 i.v.; 625 i.p.; 2120 orally (Bergamini, Fowst)
 
Derivative Type: Sodium salt
CAS Registry Number: 14897-39-3
Trademarks: Rifamastene (Uce); Rifocin (Lepetit)
Properties: Orange-red crystals. Soly in water pH 7.2: ~5 g/100 ml.
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Ansamycins.