CAS No 6834-98-6 , Fungichromin

Name: Fungichromin
Synonyms: Fungichromin;
CAS Registry Number:6834-98-6
Flash Point: 278.4°C
Boiling Point: 914°C at 760 mmHg
Density: 1.196g/cm³
Refractive index: 1.545
Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.
Flash Point: 278.4°C
EINECS: 229-913-4
Molecular Weight: 670.8278
InChI: InChI=1S/C35H58O12/c1-4-5-11-16-29(41)32-30(42)20-26(38)18-24(36)17-25(37)19-27(39)21-31(43)34(45)33(44)22(2)14-12-9-7-6-8-10-13-15-28(40)23(3)47-35(32)46/h6-10,12-15,23-34,36-45H,4-5,11,16-21H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,22-14-/t23-,24+,25-,26+,27-,28+,29-,30+,31-,32-,33-,34-/m1/s1
Molecular Formula: C35H58O12•H2O
Molecular Structure:

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           6834-98-6 Fungichromin
           Fungichromin, Min 99%
 
             Finechemie Co., Ltd. 
             
              [Manufacturer]
Tel: +86-23-99186710 
Fax: +86-23-99186729 
Address: 28th Floor Mordern Building,New-Tech Zone400020  ChongqingCHINA Chongqing,nullChina

           6834-98-6 Fungichromin
           Fungichromin
 
             CHEMOS GmbH
             
              [Manufacturer]
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Werner-von-Siemensstr. 3 
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Germany null,nullGermany

           6834-98-6 FUNGICHROMIN
           
             Nanjing Chemlin Chemical Industry Co.,Ltd.
             
              [Manufacturer]
Tel:  +86 25 8369-7070/ +86 138 51816776 (Mobile)
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Address: Rm.902 Longyin Plaza,
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(N)Nanjing 210009,China null,nullChina

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References of Fungichromin

Title: Fungichromin
CAS Registry Number: 6834-98-6
Synonyms: Antibiotic A 246; cogomycin; lagosin; pentamycin
Trademarks: Cantricin (Corvi)
Molecular Formula: C35H58O12
Molecular Weight: 670.83
Percent Composition: C 62.66%, H 8.71%, O 28.62%
Literature References: Antifungal polyene macrolide antibiotic, related structurally to filipin, q.v. Isoln from Streptomyces cellulosae: A. A. Tytell et al., Antibiot. Annu. 1954-1955, 716. Isoln (as pentamycin) from S. penticus: S. Umezawa, Y. Tanaka, J. Antibiot. 11A, 26 (1958). Isoln (as lagosin) from S. roseoluteus: C. J. Bessel et al., US 3013947 (1961 to Glaxo). Isoln from S. griseus (FCRC-21): R. C. Pandey et al., Biomed. Mass Spectrom. 7, 93 (1980). Structures: A. C. Cope, H. E. Johnson, J. Am. Chem. Soc. 80, 1504 (1958); A. C. Cope et al., ibid. 84, 2170 (1962); M. L. Dhar et al., J. Chem. Soc. 1964, 842; M. P. Berry, M. C. Whiting, ibid. 862; V. Pozgay et al., J. Antibiot. 29, 472 (1976). Identity of fungichromin with lagosin and cogomycin and comparison of reported physico-chemical constants: R. C. Pandey et al., J. Antibiot. 35, 988 (1982). Biosynthesis and NMR assignment: H. Noguchi et al., J. Am. Chem. Soc. 110, 2938 (1988).
Properties: Light yellow cryst. mp 157-162° (dec). [a]D20 -227.7° (c = 0.53 in DMF). uv max (methanol): 357, 338, 322 nm (E1%1cm 1231, 1250, 786). LD50 in mice (mg/kg): 1624 orally; 33.3 i.p. (Umezawa, Tanaka).
Melting point: mp 157-162° (dec)
Optical Rotation: [a]D20 -227.7° (c = 0.53 in DMF)
Absorption maximum: uv max (methanol): 357, 338, 322 nm (E1%1cm 1231, 1250, 786)
Toxicity data: LD50 in mice (mg/kg): 1624 orally; 33.3 i.p. (Umezawa, Tanaka)
Therap-Cat: Antifungal (topical).
Keywords: Antifungal (Antibiotics); Polyenes.