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CAS No 68247-85-8 , Bleomycin PEP

  • Name: Bleomycin PEP
  • Synonyms: Peplomycin;Bleomycine Sulfate;Pepino mosaic virusPepleomycin;Bleomycinamide,N1-[3-[[(1S)-1-phenylethyl]- amino]propyl]-;NK 631;PEPLEOMYCIN;Bleomycin PEP;BLM-PEP;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.56g/cm3
  • Refractive index: 1.688
  • Safety Statements: Poison by subcutaneous and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx. See other bleomycin entries.
  • Flash Point: °C
  • EINECS: 269-484-0
  • Molecular Weight: 1473.59
  • InChI: InChI=1/C61H88N18O21S2/c1-24-39(76-52(79-50(24)64)31(16-37(63)83)71-17-30(62)51(65)89)56(93)78-41(47(32-18-67-23-72-32)98-60-49(45(87)43(85)35(19-80)97-60)99-59-46(88)48(100-61(66)95)44(86)36(20-81)96-59)57(94)73-27(4)42(84)25(2)53(90)77-40(28(5)82)55(92)70-15-12-38-74-34(22-101-38)58-75-33(21-102-58)54(91)69-14-9-13-68-26(3)29-10-7-6-8-11-29/h6-8,10-11,18,21-23,25-28,30-31,35-36,40-49,59-60,68,71,80-82,84-88H,9,12-17,19-20,62H2,1-5H3,(H2,63,83)(H2,65,89)(H2,66,95)(H,67,72)(H,69,91)(H,70,92)(H,73,94)(H,77,90)(H,78,93)(H2,64,76,79)/t25?,26-,27?,28?,30?,31?,35-,36+,40?,41?,42?,43+,44+,45-,46-,47?,48-,49-,59+,60-/m0/s1
  • Molecular Formula: C61H88N18O21S2
  • Molecular Structure:CAS No:68247-85-8 Bleomycin PEP

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68247-85-8 Peplomycin

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
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68247-85-8 Peplomycin

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68247-85-8 PEPLOMYCIN

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References of Bleomycin PEP
Title: Peplomycin
CAS Registry Number: 68247-85-8
CAS Name: N1-[3-[[(1S)-1-Phenylethyl]amino]propyl]bleomycinamide
Synonyms: N1-[3-[[(S)-a-methylbenzyl]amino]propyl]bleomycinamide; pepleomycin
Manufacturers' Codes: NK-631
Molecular Formula: C61H88N18O21S2
Molecular Weight: 1473.59
Percent Composition: C 49.72%, H 6.02%, N 17.11%, O 22.80%, S 4.35%
Literature References: Deriv of bleomycin, q.v. with cytostatic activity and less pulmonary toxicity than the natural bleomycin mixture. Prepn of the (R,S)-form: H. Umezawa et al., US 3846400 (1974 to Microbiochem. Res. Found.); of the (S)-form: T. Takita et al., DE 2828933; eidem, US 4195018 (1979, 1980 both to Nippon Kayaku); W. Tanaka et al., Heterocycles 13, 469 (1979). Biological study of degradation products: K. Takahashi et al., J. Antibiot. 32, 36 (1979). General pharmacology: Y. Ishii et al., Jpn. J. Antibiot. 31, 886 (1978), C.A. 91, 215c (1979). Absorption, distribution, excretion, metabolism: H. Takayama et al., ibid. 895, C.A. 91, 32580j (1979). Properties and stability: A. Fuji et al., Iyakuhin Kenkyu 10, 197 (1979), C.A. 91, 9408a (1979). Effect in prostatic cancer: T. Niijima, K. Koiso, Scand. J. Respir. Dis. Suppl. 55, 177 (1980). Relative pulmonary toxicity: B. I. Sikic et al., Cancer Treat. Rep. 64, 659 (1980). Acute toxicity study: K. Ito et al., Jpn. J. Antibiot. 31, 719 (1978), C.A. 91, 68461k (1979). Review of clinical studies: S. Oko, Recent Results Cancer Res. 74, 163 (1980).
 
Derivative Type: Sulfate salt
CAS Registry Number: 70384-29-1
Trademarks: Pepleo Injection (Nippon Kayaku)
Molecular Formula: C61H88N18O21S2.H2SO4
Molecular Weight: 1571.67
Percent Composition: C 46.62%, H 5.77%, N 16.04%, O 25.45%, S 6.12%
Properties: Pale yellow amorphous powder, mp 196-198°. [a]25436 -2.0° (c = 1 in water). pKa 2.9, 4.8, 7.4, 9.0. Sol in water, methanol, acetic acid, DMSO, DMF. Slightly sol in dioxane. Insol in ethyl acetate, acetone, ether, benzene. Stable at 37° for 3 months, 50° for 6 weeks, room temp for 30 months in a sealed container. LD50 in male rats, mice (mg/kg): 234, 88 s.c.; 208, 85 i.p.; 245, 51 i.v. (Ito).
Melting point: mp 196-198°
pKa: pKa 2.9, 4.8, 7.4, 9.0
Optical Rotation: [a]25436 -2.0° (c = 1 in water)
Toxicity data: LD50 in male rats, mice (mg/kg): 234, 88 s.c.; 208, 85 i.p.; 245, 51 i.v. (Ito)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs.