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CAS No 6673-35-4 , N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide

  • Name: N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
  • Synonyms: Practololo;N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide; Eraldin; Practololum; Teranol; Praktololu [Polish]; Praktololu; Practololo [DCIT];Dalzic; ICI 50172;
  • CAS Registry Number:
  • Flash Point: 252.3°C
  • Boiling Point: 493.6°C at 760 mmHg
  • Density: 1.127 g/cm3
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Human systemic effects by ingestion: eye damage, peritonitis, and dermatitis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 252.3°C
  • EINECS: 229-712-1
  • Molecular Weight: 266.33608
  • InchiKey: DURULFYMVIFBIR-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/
    h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
  • Molecular Formula: C14H22N2O3
  • Molecular Structure:CAS No:6673-35-4 N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide

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References of N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
Title: Practolol
CAS Registry Number: 6673-35-4
CAS Name: N-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide
Synonyms: 4￠-[2-hydroxy-3-(isopropylamino)propoxy]acetanilide; 1-(4-acetamidophenoxy)-3-isopropylamino-2-propanol
Manufacturers' Codes: AY-21011; ICI-50172
Trademarks: Dalzic (Zeneca); Eraldin (Zeneca)
Molecular Formula: C14H22N2O3
Molecular Weight: 266.34
Percent Composition: C 63.13%, H 8.33%, N 10.52%, O 18.02%
Literature References: b-Adrenergic blocker. Prepn: Howe, Smith, NL 6512676; eidem, US 3408387 (1966, 1968, to I.C.I.). Synthesis of R(+)-form: Danilewicz, Kemp, J. Med. Chem. 16, 168 (1973). Pharmacological studies: Dunlop, Shanks, Br. J. Pharmacol. Chemother. 32, 201 (1968); Barrett, Postgrad. Med. J. Suppl. 47, 7 (1971). Metabolic studies: Scales, Cosgrove, J. Pharmacol. Exp. Ther. 175, 338 (1970).
Properties: mp 134-136° (BuOAc). Sol in warm isopropanol.
Melting point: mp 134-136° (BuOAc)
 
Derivative Type: Hydrochloride monohydrate
Properties: mp 140-142°.
Melting point: mp 140-142°
 
Derivative Type: R(+)-Form
Properties: Crystals from dioxane, mp 130-131.5°. [a]25365 +4.3°, [a]25578 +3.5° (ethanol).
Melting point: mp 130-131.5°
Optical Rotation: [a]25365 +4.3°; [a]25578 +3.5° (ethanol)
 
Derivative Type: R(+)-Hydrochloride
Properties: [a]25436+26.0°, [a]25578 +14.0°.
Optical Rotation: [a]25436+26.0°; [a]25578 +14.0°
 
Therap-Cat: Antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antiarrhythmic.