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CAS No 6620-60-6 , 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid

  • Name: 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
  • Synonyms: Gastrotopic; Binoside;4-benzamido-5-(dipropylamino)-5-oxopentanoic acid; Milide; Midelid; dl-proglumide; Xylamide; Ulcutin;Nulsa; Xyde;
  • CAS Registry Number:
  • Melting Point: 148.5--152ºC
  • Density: 1.136 g/cm3
  • Refractive index: 1.534
  • Water Solubility: very slightly soluble in water, freely soluble in methanol,soluble in ethanol
  • Safety Statements: Moderately toxic by several routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 229-567-4
  • Molecular Weight: 334.41004
  • InchiKey: DGMKFQYCZXERLX-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)
    14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
  • Molecular Formula: C18H26N2O4
  • Molecular Structure:CAS No:6620-60-6 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid

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References of 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
Title: Proglumide
CAS Registry Number: 6620-60-6
CAS Name: 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid
Synonyms: DL-4-benzamido-N,N-dipropylglutaramic acid; N-benzoyl-N￠,N￠-di-n-propyl-DL-isoglutamine; xylamide
Manufacturers' Codes: CR-242; W-5219
Trademarks: Milid (Opfermann); Milide (Beytout); Promid (Kaken)
Molecular Formula: C18H26N2O4
Molecular Weight: 334.41
Percent Composition: C 64.65%, H 7.84%, N 8.38%, O 19.14%
Literature References: Prepn: NL 6510006; ZA 6504065 (both 1966 to Rotta), C.A. 65, 3793b (1966). Pharmacological activity: A. L. Rovati et al., Minerva Med. 58, 3653 (1967); T. Umetzu et al., Eur. J. Pharmacol. 64, 69 (1980). Pharmacokinetic study: A. A. Bignamini et al., Arzneim.-Forsch. 29, 639 (1979). Clinical study in duodenal ulcer: W. Bergemann et al., Med. Klin. 76, 226 (1981). Cholecystokinin receptor antagonist activity: W. F. Hahne et al., Proc. Natl. Acad. Sci. USA 78, 6304 (1981). Selective blockade of cholecystokinin CNS effects: L. A. Chiodo, B. S. Bunney, Science 219, 1449 (1983).
Properties: Crystals, mp 142-145°. LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati).
Melting point: mp 142-145°
Toxicity data: LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati)
Therap-Cat: Anticholinergic.
Keywords: CCK Antagonist.