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CAS No 645-05-6 , 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine Search by region : China

  • Name: 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine
  • Synonyms: Melamine;Hexalen; Hemel;2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine; 645-05-6; hexamethyl-; HEXAMETHYLMELAMINE; Hexastat; Altretaminum; Altretamina;
  • CAS Registry Number:
  • Boiling Point: 301
  • Density: 1.148 g/cm3
  • Refractive index: 1.569
  • Water Solubility: Insoluble
  • Safety Statements: A poison by ingestion, intraperitoneal, and intravenous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. Human systemic effects by ingestion: nausea or vomiting and leukopenia (reduced white blood cell count). When heated to decomposition it emits toxic fumes of NOx. See also AMINES.
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 211-428-4
  • Molecular Weight: 210.27942
  • InchiKey: UUVWYPNAQBNQJQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3
  • Risk Statements: R22;R36/37/38
  • Molecular Formula: C9H18N6
  • Molecular Structure:CAS No:645-05-6 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine

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References of 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine
Title: Altretamine
CAS Registry Number: 645-05-6
CAS Name: N,N,N￠,N￠,N￠￠,N￠￠-Hexamethyl-1,3,5-triazine-2,4,6-triamine
Synonyms: 2,4,6-tris(dimethylamino)-s-triazine; hemel; hexamethylmelamine; HMM
Manufacturers' Codes: ENT-50852; NSC-13875
Trademarks: Hexalen (U.S. Bioscience); Hexastat (Bellon)
Molecular Formula: C9H18N6
Molecular Weight: 210.28
Percent Composition: C 51.41%, H 8.63%, N 39.97%
Literature References: An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Synthesis: A. W. Hofmann, Ber. 18, 2755 (1885); D. W. Kaiser et al., J. Am. Chem. Soc. 73, 2984 (1951); Y. Bessiere-Chretien, H. Serne, Bull. Soc. Chim. Fr. 6, 2039 (1973). Production process: H. von Brachel, H. Kindler, DE 1240870; eidem, US 3424752 (1967, 1969 both to Casella Farbwerke). Chemosterilant effect: S. C. Chang et al., Science 144, 57 (1964); A. De Milo et al., J. Econ. Entomol. 65, 1548 (1972). Chromatographic detn in plasma or serum: A. Hulshoff et al., J. Chromatogr. 181, 363 (1980). Disposition and metabolism in rabbits and humans: M. M. Ames et al., Cancer Res. 39, 5016 (1979). Evaluation in breast cancer: C. J. Fabian et al., Cancer Treat. Rep. 63, 1359 (1979); in ovarian cancer: J. T. Wharton et al., Am. J. Obstet. Gynecol. 133, 833 (1979). Mammalian toxicity study: R. L. Jasper et al., Fed. Proc. 24, 641 (1965). Toxicological studies in dogs and mice: D. C. Thake et al., Gov. Rep. Announce. Index (USA) 79, 92 (1979), C.A. 91, 168372a (1979). In vitro cytotoxicity study: M. D'Incalci et al., Br. J. Cancer 41, 630 (1980).
Properties: Needles from abs ethanol, mp 172-174°. uv max (ethanol): 226 nm (e 49400), H. J. Anderson et al., Can. J. Chem. 49, 2315 (1971). LD50 in rats, guinea pigs (mg/kg): 350, 255 orally (Jasper).
Melting point: mp 172-174°
Absorption maximum: uv max (ethanol): 226 nm (e 49400), H. J. Anderson et al., Can. J. Chem. 49, 2315 (1971)
Toxicity data: LD50 in rats, guinea pigs (mg/kg): 350, 255 orally (Jasper)
Use: As exptl insect chemosterilant.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Ethylenimines and Methylmelamines.