Home > Name List By e > Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl- Germany

CAS No 64285-06-9 , Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl- Search by region : Germany

  • Name: Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl-
  • Synonyms: Anatoxin a;Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl-; (+)-Anatoxin-a; 9-Azabicyclo[4.2.1]nonane,ethanone deriv.; Anatoxin I; (+)-Anatoxin a;Ethanone,1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-, (1R)-;
  • CAS Registry Number:
  • Density: 1.037 g/cm3
  • Refractive index: 1.503
  • Water Solubility: Soluble to 50 mM in Water
  • Safety Statements: Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
  • Molecular Weight: 165.26
  • InChI: InChI=1S/C10H15NO/c1-7(12)9-4-2-3-8-5-6-10(9)11-8/h4,8,10-11H,2-3,5-6H2,1H3/t8-,10-/m1/s1
  • Molecular Formula: C10H15 N O
  • Molecular Structure:CAS No:64285-06-9 Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl-

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References of Ethanone,1-(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl-
Title: Anatoxins
Synonyms: ANTXS
Literature References: First isolated, freshwater neurotoxins present in algal blooms associated with a number of blue-green cyanobacteria including Anabaena. spp., Aphanizomenon spp. and Oscillatoria spp. Responsible for fatal poisoning of cattle and wildlife as well as human illness worldwide. Review: W. W. Carmichael et al., ACS Symp. Ser. 418, 87-106 (1990). Review of occurence, chemistry and analysis: K. Sivonen, Food Sci. Technol. 103, 567-581 (2000).
 
Derivative Type: Anatoxin a
CAS Registry Number: 64285-06-9
CAS Name: 1-(1R,6R)-9-Azabicyclo[4.2.1]non-2-en-2-ylethanone
Synonyms: 2-acetyl-9-azabicyclo[4.2.1]non-2ene; (+)-ANTX-a; Very Fast Death Factor
Molecular Formula: C10H15NO
Molecular Weight: 165.23
Percent Composition: C 72.69%, H 9.15%, N 8.48%, O 9.68%
Literature References: Alkaloid post-synaptic depolarizing neuromuscular blocker acting as a nicotinic cholinergic receptor agonist. Isoln and purification: J. P. Devlin et al., Can. J. Chem. 55, 1367 (1977). Improved purification: K. Harada et al., Toxicon 27, 1289 (1989). Synthesis: H. F. Campbell et al., Can. J. Chem. 55, 1372 (1977); stereoselective synthesis: M. Skrinjar et al., Tetrahedron: Asymmetry 3, 1263 (1992). TLC determn in algal material: I. Ojanpera et al., Analyst 116, 265 (1991); by LC/MS in cyanobacteria and drinking water: A. Furey et al., Rapid Commun. Mass Spectrom. 17, 583 (2003). Review of syntheses: H. L. Mansell, Tetrahedron 52, 6025-6061 (1996).
Properties: [a]D25 +39.8° (c = 0.676 in abs. ethanol). pKa: 9.4 Degrades readily in sunlight and high pH to non-toxic products. LD50 i.p. in mice: 200 mg/kg (Carmichael).
pKa: pKa: 9.4
Optical Rotation: [a]D25 +39.8°
Toxicity data: LD50 i.p. in mice: 200 mg/kg (Carmichael)
 
Derivative Type: Anatoxin a(s)
CAS Registry Number: 103170-78-1
CAS Name: (5S)-2-Amino-4,5-dihydro-1-[(hydroxymethoxyphosphinyl)oxy]-N,N-dimethyl-1H-imidazole-5-methanamine
Synonyms: ANTX-a(s)
Molecular Formula: C7H17N4O4P
Molecular Weight: 252.21
Percent Composition: C 33.34%, H 6.79%, N 22.21%, O 25.37%, P 12.28%
Literature References: Irreversible acetylcholinesterase inhibitor; only known organophosphate toxin found in cyanobacteria. The (s) refers to the production of excess saliva upon ingestion. Identification and preliminary purification: N. A. Mahmood, W. W. Carmichael, Toxicon 24, 425 (1986); anticholinesterase activity: eidem, ibid. 25, 1221 (1987). Mechanism of action: E. G. Hyde, W. W. Carmichael, J. Biochem. Toxicol. 6, 195 (1991). Pharmacology in rat: W. O. Cook et al., J. Environ. Pathol. Toxicol. Oncol. 9, 393, (1989). Biosensor determn in water: F. Villatte et al., Anal. Bioanal. Chem. 372, 322 (2002).
Properties: Stable in neutral or acid conditions. LD50 i.p. in mice: 20 mg/kg (Carmichael).
Toxicity data: Stable in neutral or acid conditions. LD50 i.p. in mice: 20 mg/kg (Carmichael)
 
CAUTION: Overexposure in animals has caused muscle fasciculation, gasping and convulsions and death due to respiratory arrest. Anatoxin a(s) also causes salivation. (Carmichael).