References of (2Z,6E)-2-[(3E)-4,8-dimethylnona-3,7-dienyl]-6-methylocta-2,6-diene-1,
8-diol
Title: Plaunotol
CAS Registry Number: 64218-02-6
CAS Name: (2
Z,6
E)-2-[(3
E)-4,8-Dimethyl-3,7-nonadienyl]-6-methyl-2,6-octadiene-1,8-diol
Synonyms: (E,Z,E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol
Manufacturers' Codes: CS-684
Trademarks: Kelnac (Sankyo)
Molecular Formula: C20H34O2
Molecular Weight: 306.48
Percent Composition: C 78.38%, H 11.18%, O 10.44%
Literature References: Acyclic diterpene alcohol isolated from a Thai medicinal plant identified as
Croton sublyratus Kurz,
Euphorbiaceae. Isoln, synthesis and anti-ulcer activity: H. Mishima
et al., JP Kokai 77 62213;
eidem, US 4059641 (both 1977 to Sankyo); A. Ogiso
et al., Chem. Pharm. Bull. 26, 3117 (1978). Pharmacology: S. Kobayashi
et al., Oyo Yakuri 24, 599 (1982).
Properties: Light yellow oil. Aromatic odor, bitter taste. Sol in benzene, acetone, alcohols, ethers. Insol in water. LD50 in male, female mice, rats (ml/kg): 8800, 8100, 10900, 11200 orally (Kobayashi).
Toxicity data: LD50 in male, female mice, rats (ml/kg): 8800, 8100, 10900, 11200 orally (Kobayashi)
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Cytoprotectant (Gastric).