CAS No 6377-18-0 , Benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione,10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-a-D-galactopyranosyl)-b-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl- Search by region : Germany

Name: Benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione,10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-a-D-galactopyranosyl)-b-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-
Synonyms: Lambdamycin; Antibiotic X 465A; NSC 5159;Benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione,10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-a-D-galactopyranosyl)-b-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-;Chartreusin(7CI,8CI);
CAS Registry Number:6377-18-0
Flash Point: 307.8°C
Boiling Point: 945.5°C at 760 mmHg
Density: 1.63g/cm³
Refractive index: 1.718
Safety Statements: Poison by intraperitoneal route. Moderately toxic by subcutaneous route. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Flash Point: 307.8°C
Molecular Weight: 640.64
InChI: InChI=1/C32H32O14/c1-10-8-9-15-18-16(10)29(38)45-26-17-13(23(35)20(19(18)26)30(39)43-15)6-5-7-14(17)44-32-28(24(36)21(33)11(2)42-32)46-31-25(37)27(40-4)22(34)12(3)41-31/h5-9,11-12,21-22,24-25,27-28,31-37H,1-4H3
Molecular Formula: C32H32 O14
Molecular Structure:

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6377-18-0 CHARTREUSIN

Cfm Oskar Tropitzsch [Manufacturer]
Tel: +49-9231-9619-0
Fax: +49-9231-9619-60
Address: Cfm Oskar Tropitzsch
Waldershofer Str. 49-51
95615 Marktredwitz
Germany null,nullGermany

6377-18-0 Chartreusin, Lambdamycin

Chartreusin, Lambdamycin
ChemCon GmbH [Manufacturer]
Tel: +49-(0)761-5597-44-0
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References of Benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione,10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-a-D-galactopyranosyl)-b-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-

Title: Chartreusin
CAS Registry Number: 6377-18-0
CAS Name: 10-[[6-Deoxy-2-O-(6-deoxy-3-O-methyl-a-D-galactopyranosyl)-b-D-galactopyranosyl]oxy]-6-hydroxy-1-methylbenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione
Synonyms: antibiotic X-465A; lambdamycin
Manufacturers' Codes: NSC-5159
Molecular Formula: C32H32O14
Molecular Weight: 640.59
Percent Composition: C 60.00%, H 5.04%, O 34.97%
Literature References: Antibiotic substance produced by Streptomyces chartreusis from African soil, also by another Streptomyces sp. from North American soil: B. E. Leach et al., J. Am. Chem. Soc. 75, 4011 (1953). Identity with Antibiotic X-465A: J. Berger et al., ibid. 80, 1636 (1958). Structure: L. H. Sternbach et al., ibid. 1639; E. Simonitsch et al., Helv. Chim. Acta 47, 1459 (1964); W. Eisenhuth et al., ibid. 1475. Anticancer activity: J. P. McGovern et al., Cancer Res. 37, 1666 (1977). Synthesis of chartarin, the chartreusin aglycone: T. R. Kelly et al., J. Am. Chem. Soc. 102, 798 (1980); F. M. Hauser, D.W. Combs, J. Org. Chem. 45, 4071 (1980).
Properties: Yellow plates from acetone or methylene chloride + ethanol, mp 184-186°. Weak acid. [a]D25 +132.5° (c = 0.2 in pyridine); [a]D25 -33° (c = 0.3 in glacial acetic acid). uv max: 237, 262, 332, 382, 405, 422 nm. Practically insol in water. Sol in acetone.
Melting point: mp 184-186°
Optical Rotation: [a]D25 +132.5° (c = 0.2 in pyridine); [a]D25 -33° (c = 0.3 in glacial acetic acid)
Absorption maximum: uv max: 237, 262, 332, 382, 405, 422 nm

Derivative Type: Sodium salt
Properties: Gold-colored needles or plates from water. Soly in water: at least 20 mg/ml (pH 9.5). LD50 i.v. in mice: 250 mg/kg (Leach).
Toxicity data: LD50 i.v. in mice: 250 mg/kg (Leach)