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CAS No 63585-09-1 , Foscarnet sodium

  • Name: Foscarnet sodium
  • Synonyms: Trisodium phosphonoformate; Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt; Phosphonoformic acid trisodium salt; Trisodium carboxyphosphate; Phosphonoformic acid, trisodium salt; Foscarnet sodium;Foscavir;Foscarnet sodium; Trisodium carboxyphosphate; Trisodium phosphonoformate;
  • CAS Registry Number:
  • Melting Point: >250
  • Molecular Weight: 191.95
  • InChI: InChI=1/CH3O5P.3Na/c2-1(3)7(4,5)6;;;/h(H,2,3)(H2,4,5,6);;;/q;3*+1/p-3
  • Molecular Formula: CNa3O5P
  • Molecular Structure:CAS No:63585-09-1 Foscarnet sodium

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References of Foscarnet sodium
Title: Foscarnet Sodium
CAS Registry Number: 63585-09-1
CAS Name: Dihydroxyphosphinecarboxylic acid oxide trisodium salt
Synonyms: trisodium phosphonoformate; trisodium carboxyphosphate
Manufacturers' Codes: A-29622
Trademarks: Foscavir (AstraZeneca)
Molecular Formula: CNa3O5P
Molecular Weight: 191.95
Percent Composition: C 6.26%, Na 35.93%, O 41.68%, P 16.14%
Literature References: Inhibits viral DNA polymerase and reverse transcriptase. Prepn: P. Nylén, Ber. 57B, 1023 (1924). Crystal structure: R. R. Naqvi et al., J. Chem. Soc. A 1971, 2751; S. C. Abrahams, Acta Crystallogr. B28, 2886 (1972). Use as antiviral agent: B. F. H. Eriksson et al., DE 2728685; eidem, US 4215113 (1978, 1980 both to Astra). Activity against herpes simplex virus: E. Helgstrand et al., Science 201, 819 (1978); J. M. Reno et al., Antimicrob. Agents Chemother. 13, 188 (1978); S. Alenius et al., Arch. Virol. 60, 197 (1979). Mechanism of inhibition of Epstein-Barr virus replication: A. K. Datta, R. E. Hood, Virology 114, 52 (1981). Preclinical evaluation: B. Oeberg et al., Int. Congr. Ser. - Excerpta Med. 571, 175 (1982). Inhibitory effect on HIV-1 (HTLV-III/LAV) virus replication in vitro: P. S. Sarin et al., Biochem. Pharmacol. 34, 4075 (1985).
Properties: Hexahydrate, mp >250°. LD50 i.p. in mice: 2000-4000 mmol/kg (Eriksson).
Melting point: mp >250°
Toxicity data: LD50 i.p. in mice: 2000-4000 mmol/kg (Eriksson)
Therap-Cat: Antiviral.
Keywords: Antiviral; Reverse Transcriptase Inhibitor.